Correlation between the expression of aquaporin 1 and hypoxia-inducible factor 1 in breast cancer tissues

被引：0
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作者：
Tiejun Yin
Shiying Yu
Liang Xiao
Jun Zhang
Chong Liu
Yunping Lu
Chengping Liu
机构：
[1] Tongji Hospital,Department of Comprehensive Medicine
[2] Tongji Medical College,Department of Oncology
[3] Huazhong University of Science and Technology,Department of Pathology
[4] Tongji Hospital,Department of Obstetrics and Gynecology
[5] Tongji Medical College,Department of Mathmatics
[6] Huazhong University of Science and Technology,undefined
[7] Tongji Hospital,undefined
[8] Tongji Medical College,undefined
[9] Huazhong University of Science and Technology,undefined
[10] Tongji Hospital,undefined
[11] Tongji Medical College,undefined
[12] Huazhong University of Science and Technology,undefined
[13] Huazhong University of Agriculture,undefined
来源：
Journal of Huazhong University of Science and Technology [Medical Sciences] | 2008年 / 28卷
关键词：
aquaporin 1; hypoxia-inducible factor 1; breast cancer; correlation;
D O I：
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中图分类号：
学科分类号：
摘要：
The correlation between aquaporin 1 (AQP1) and hypoxia-inducible factor 1 (HIF 1) in breast cancer tissues was preliminarily studied. In 155 cases of breast cancer, the expression levels of AQP1 were detected by immunohistochemisty in HIF1-positive group or HIF1-negative group, and the correlation between AQP1 and HIF1 was analyzed. The overexpression of AQP1 and HIF1 were observed in 155 cases of breast cancer tissues. The expression level of AQP1 in HIF1-positive group was significantly higher than that in HIF1-negative group. The positive expression rate of AQP1 was 296.55±24.67 and 168.37±37.53 in HIF1-positive group and HIF1-negative group respectively with the difference being very significant between them (P<0.001). It was concluded that AQP1 was overexpressed in the HIF1-positive group and there were some correlations between AQP1 and HIF1, suggesting they interact each other and regulate the oncogenesis of breast cancer.
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