Endogenous soluble receptor of advanced glycation end-products (esRAGE) is negatively associated with vascular calcification in non-diabetic hemodialysis patients

被引：5
作者：
NasrAllah M.M. [1 ]
El-Shehaby A.R. [2 ]
Osman N.A. [1 ]
Salem M.M. [3 ]
Nassef A. [4 ]
Sharaf El Din U.A.A. [1 ,5 ]
机构：
[1] Department of Nephrology, Kasr El-Aini School of Medicine, Cairo University, Cairo
[2] Department of Medical Biochemistry, Kasr El-Aini School of Medicine, Cairo University, Cairo
[3] Department of Endocrinology, Kasr El-Aini School of Medicine, Cairo University, Cairo
[4] Department of Radiology, Kasr El-Aini School of Medicine, Cairo University, Cairo
[5] Department of Nephrology, Kasr El-Aini School of Medicine, Cairo University and International Kidney Centre, Cairo
来源：
International Urology and Nephrology | 2012年 / 44卷 / 4期
关键词：
Advanced glycation end-products; CKD-MBD; HsCRP; Inflammation; RAGE; Vascular calcification;
D O I：
10.1007/s11255-011-0007-x
中图分类号：
学科分类号：
摘要：
Background: Advanced glycation end-products (AGE) accumulate in CKD and may predispose to cardiovascular disease by inducing inflammatory and oxidant stress in the vascular endothelium. Soluble forms of the receptor for AGE (RAGE) may be protective against these effects by binding AGE in the soluble phase. Accumulating evidence suggests a protective role of soluble RAGE against vascular calcification. This study investigates the association between endogenous soluble RAGE (esRAGE) and vascular calcification in hemodialysis patients. Methods: We studied 65 non-diabetic hemodialysis patients, on 3 9 4 h dialysis schedule, and 19 controls. Serum levels of esRAGE, hsCRP, parathormone, lipids, calcium, and phosphorus were measured. Aortic calcification index (ACI) was measured using non-contrast CT of the abdominal aorta. Results: Aortic calcification was detected in 64 out of 65 hemodialysis patients. Levels of esRAGE were lower in hemodialysis patients (278 pg/ml, SD 101.1) than in controls (443 ± 109 pg/ml; P = 0.001). ACI correlated negatively in stepwise multivariate analysis with esRAGE (P = 0.002) and positively with hsCRP (<0.0001), systolic blood pressure (P<0.0001) and dialysis vintage (P = 0.05); R2 = 0.65. Conclusion: Levels of esRAGE were low among hemodialysis patients and correlated negatively with ACI. © Springer Science+Business Media, B.V. 2011.
引用
收藏
页码：1193 / 1199
页数：6
相关论文
共 37 条
  • [1] Adragao T., Pires A., Birne R., Et al., A plain X-ray vascular calcification score is associated with arterial stiffness and mortality in dialysis patients, Nephrol Dial Transplant, 24, pp. 997-1002, (2009)
  • [2] Okuno S., Ishimura E., Kitatani K., Et al., Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients, Am J Kidney Dis, 49, pp. 417-425, (2007)
  • [3] London G.M., Gue'Rin A.P., Marchais S.J., Et al., Arterial media calcification in end-stage renal disease: Impact on all-cause and cardiovascular mortality, Nephrol Dial Transplant, 18, pp. 1731-1740, (2003)
  • [4] Cannata-Andia J.B., Rodriguez-Garcia M., Carrillo-Lopez N., Et al., Vascular calcifications: Pathogenesis, management, and impact on clinical outcomes, J Am Soc Nephrol, 17, pp. 267-273, (2006)
  • [5] Goodman W., London G., Vascular calcification in chronic kidney disease, Am J Kid Dis, 43, pp. 572-579, (2004)
  • [6] Nasrallah M.M., El-Shehaby A.R., Salem M.M., Et al., Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients, Nephrol Dial Transplant, 25, pp. 2679-2685, (2010)
  • [7] Ketteler M., Fetuin-A and extraosseous calcification in uremia, Curr Opin Nephrol Hypertens, 14, 4, pp. 337-342, (2005)
  • [8] Jono S., Shioi A., Ikari Y., Nishizawa Y., Vascular calcification in chronic kidney disease, J Bone Miner Metab, 24, 2, pp. 176-181, (2006)
  • [9] Nikolov I., Joki N., Drueke T., Et al., Beyond phosphate-role of uraemic toxins in cardiovascular calcification, Nephrol Dial Transplant, 21, pp. 3354-3357, (2006)
  • [10] Meerwaldt R., Zeebregts C.J., Navis G., Et al., Accumulation of advanced glycation end products and chronic complications in ESRD treated by dialysis, Am J Kidney Dis, 53, pp. 138-150, (2009)
1234