Hyperphosphataemia in Renal FailuresCauses, Consequences and Current Management

被引:0
作者
Fouad Albaaj
Alastair J. Hutchison
机构
[1] Manchester Institute of Nephrology and Transplantation,
[2] The Royal Infirmary,undefined
来源
Drugs | 2003年 / 63卷
关键词
Phosphate Binder; Sevelamer; Lanthanum Carbonate; Serum Phosphate Level; Calcium Acetate;
D O I
暂无
中图分类号
学科分类号
摘要
Hyperphosphataemia is prevalent among chronic renal failure and dialysis patients. It is known to stimulate parathyroid hormone and suppress vitamin D3 production, thereby inducing hyperparathyroid bone disease. In addition, it may independently contribute to cardiac causes of death through increased myocardial calcification and enhanced vascular calcification. Hyperphosphataemia is also associated with cardiac microcirculatory abnormalities. Therefore, phosphate control is of prime importance.
引用
收藏
页码:577 / 596
页数:19
相关论文
共 315 条
  • [1] Block GA(1998)Association of serum phosphorus and calcium X phosphate product with mortality risk in chronic haemodialysis patients: a national study Am J Kidney Dis 31 607-17
  • [2] Hulbert-Shearon TE(1990)death risk in haemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities Am J Kidney Dis 15 458-82
  • [3] Lowrie EG(1992)Hyperphosphataemia: its consequences and treatment in patients with chronic renal disease Am J Kid Dis 4 303-17
  • [4] Lew NL(1999)Understanding and managing hyperphosphataemia in patients with chronic renal disease Clin Nephrol 52 267-77
  • [5] Delmez J(1969)Relation of plasma phosphorus concentration to renal tubular reabsorption of phosphate Clin Sci 37 26-10
  • [6] Slatopolsky E(1975)Nomogram for the derivation of renal threshold phosphate concentration Lancet II 309-74
  • [7] Malluche HH(1968)Control of phosphate excretion in uraemic man J Clin Invest 47 1865-75
  • [8] Monier-Faugere MC(1995)Mechanisms of disease: renal osteodystrophy N Engl J Med 333 166-53
  • [9] Bijvoet OLM(1969)Calcium, phosphorus and bone in renal disease and transplantation Arch Intern Med 123 543-40
  • [10] Walton RJ(1996)Phosphate restriction prevents parathyroid cell growth in uremic rats and high phosphate directly stimulates PTH secretion in tissue culture J Clin Invest 97 2534-52