On the immunoregulatory role of statins in multiple sclerosis: the effects on Th17 cells

被引：0
|
作者：
Georgios Ntolkeras
Chrysanthi Barba
Athanasios Mavropoulos
Georgios K. Vasileiadis
Efthymios Dardiotis
Lazaros I. Sakkas
Georgios Hadjigeorgiou
Dimitrios P. Bogdanos
机构：
[1] University General Hospital of Larissa,Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences
[2] University of Thessaly,Department of Neurology and Laboratory of Neurogenetics, Faculty of Medicine, School of Health Sciences
[3] University General Hospital of Larissa,Department of Neurology
[4] University of Thessaly,undefined
[5] University of Cyprus Medical School,undefined
来源：
Immunologic Research | 2019年 / 67卷
关键词：
Autoimmunity; Demyelination; Inflammation; Regulation; Statin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Statins, the cholesterol-lowering drugs, also possess immunomodulatory properties, affecting among others T cell activation and differentiation, antigen presentation, and regulatory T cell (Tregs) maintenance and differentiation. Their effects on autoagression have led investigators to assess their clinical significance in autoimmune disease, such as multiple sclerosis (MS), a chronic progressive demyelinating disease of autoimmune nature. The dysregulated immunity noted in MS features a profound shift from Tregs dominance to Th17 cell superiority. In this review, we discuss the immunobiological basis of statins, their role in autoimmunity related to MS, and the data from experimental models and human studies on their effect on Th17 cells.
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页码：310 / 324
页数：14
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