Lack of effectiveness of dexamethasone in neonatal bacterial meningitis

被引：0

作者：

A. S. Daoud

A. Batieha

M. Al-Sheyyab

F. Abuekteish

A. Obeidat

T. Mahafza

机构：

[1] Department of Pediatrics,

[2] Jordan University of Science & Technology,undefined

[3] Faculty of Medicine,undefined

[4] P.O. Box 30309,undefined

[5] Irbid,undefined

[6] Jordan,undefined

[7] e-mail: daoud@just.edu.jo,undefined

[8] Tel.: +962-2-7101093,undefined

[9] Fax: +962-2-295123,undefined

[10] Department of Community Medicine,undefined

[11] Jordan University of Science and Technology,undefined

[12] Jordan,undefined

[13] The Neonatal Unit of Princess Badia Teaching Hospital,undefined

[14] Irbid,undefined

[15] Jordan,undefined

[16] P.O. Box 2233,undefined

[17] Department of Otolaryngology,undefined

[18] Jordan University of Science and Technology,undefined

[19] Jordan,undefined

来源：

European Journal of Pediatrics | 1999年 / 158卷

关键词：

Key words Dexamethasone; Neonate; Bacterial meningitis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A clinical trial was conducted to determine whether dexamethasone as adjunctive therapy alters the outcome of bacterial meningitis in neonates. Fifty-two full-term neonates with bacterial meningitis were enrolled in a prospective study. Infants were alternately assigned to receive either dexamethasone or not. Twenty-seven received dexamethasone in addition to standard antibiotic treatment and 25 received antibiotics alone. Dexamethasone therapy was started 10–15 min before the first dose of antibiotics in a dose of 0.15 mg/kg per 6 h for 4 days. Baseline characteristics, clinical and laboratory features in the two groups were virtually similar. Both groups showed a similar clinical response and similar frequency of mortality and sequelae. Six (22%) babies in the treatment group died compared to 7 (28%) in the control group (P = 0.87). At follow up examinations up to the age of 2 years, 6 (30%) of dexamethasone recipients and 7 (39%) of the control group had mild or moderate/severe neurological sequelae. Audiological sequelae were seen in two neonates in the dexamethasone group compared to one in the control group.

引用

页码：230 / 233

页数：3