Two New Triterpene Glycosides from the Vietnamese Sea CucumberHolothuria scabra

被引：0
作者：
Nguyen Hai Dang
Nguyen Van Thanh
Phan Van Kiem
Le Mai Huong
Chau Van Minh
Young Ho Kim
机构：
[1] Chungnam National University,College of Pharmacy
[2] Vietnamese Academy of Science and Technology,Institute of Natural Products Chemistry
来源：
Archives of Pharmacal Research | 2007年 / 30卷
关键词：
Sea cucumber; Triterpene glycoside; Holothurin A; Holothurin A;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two new triterpene glycosides, namely holothurin A3 (1) and A4 (2) were isolated from the methanol extract of the sea cucumber,Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 2D NMR, ESI-MS and HRESI-MS). Compounds1 and2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations (IC50) of 0.87 and 0.32 μg/mL (for compound 1) and of 1.12 and 0.57 μg/mL (for compound2), respectively.
引用
收藏
页码：1387 / 1391
页数：4
相关论文
共 67 条
  • [11] Yamasaki K.(2006), and B Asean Journal on Science & Technology for Development 23 253-259
  • [12] Kitagawa I.(1992): Minor triterpene glycosides from the New Zealand and South Australian sea cucumber Phytochemistry 31 2455-2458
  • [13] Nishino T.(2006)Holothurins B J. Nat. Prod. 69 1492-1495
  • [14] Kobayashi M.(2003), B J. Nat. Prod. 66 1055-1060
  • [15] Matsuno T.(undefined), and B undefined undefined undefined-undefined
  • [16] Akutsu H.(undefined), new triterpene glycosides from mediterranean sea cucumber of the genus undefined undefined undefined-undefined
  • [17] Kyogoku Y.(undefined)Some terpenoid and steroid derivatives from echinoderms and sponges undefined undefined undefined-undefined
  • [18] Kitagawa I.(undefined)A new triterpene glycoside from the sea cucumber undefined undefined undefined-undefined
  • [19] Nishino T.(undefined) collected in Vietnam undefined undefined undefined-undefined
  • [20] Kobayashi H.(undefined)Cycloartane-type sapogenins and their glycosides from undefined undefined undefined-undefined
1234567