Two New Triterpene Glycosides from the Vietnamese Sea CucumberHolothuria scabra

被引:0
作者
Nguyen Hai Dang
Nguyen Van Thanh
Phan Van Kiem
Le Mai Huong
Chau Van Minh
Young Ho Kim
机构
[1] Chungnam National University,College of Pharmacy
[2] Vietnamese Academy of Science and Technology,Institute of Natural Products Chemistry
来源
Archives of Pharmacal Research | 2007年 / 30卷
关键词
Sea cucumber; Triterpene glycoside; Holothurin A; Holothurin A;
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摘要
Two new triterpene glycosides, namely holothurin A3 (1) and A4 (2) were isolated from the methanol extract of the sea cucumber,Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 2D NMR, ESI-MS and HRESI-MS). Compounds1 and2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations (IC50) of 0.87 and 0.32 μg/mL (for compound 1) and of 1.12 and 0.57 μg/mL (for compound2), respectively.
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页码:1387 / 1391
页数:4
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  • [1] Chludil H. D.(2002)Cytotoxic and antifungal triterpene glycosides from the patagonian sea cucumber J. Nat. Prod. 65 860-865
  • [2] Muniain C. C.(2005)Triterpenoid oligoglycosides from the sea cucumber J. Nat. Prod. 68 1669-1673
  • [3] Seldes A.M.(2002)Cucurbitane, hexanorcucurbitane, and octanorcucurbitane glycosides from fruits of Phytochemistry 59 215-228
  • [4] Maier M. S.(1981)Marine natural products, VII. Bioactive triterpene-oligoglycosides from the sea cucumber Chem. Pharm. Bull. 29 1942-1950
  • [5] Iniguez-M A. M.(1981) Brandt (1). Structure of holothurin B Chem. Pharm. Bull. 29 1951-1956
  • [6] Guerra-R M.(2003)Marine natural products, VIII. Bioactive triterpene-oligoglycosides from the sea cucumber Bioorg. Med. Chem. 11 4791-4796
  • [7] Rios T.(1993) Bandt (2). Structure of holothurin A J. Nat. Prod. 56 30-38
  • [8] Quijano L.(2005)Synthesis and cytotoxicity evaluation of pyridin[2, 3-f]indole-2,4,9-trione and benz[f]indole-2,4,9-trione derivaties J. Nat. Prod. 68 842- 847
  • [9] Kanchanapoom T.(2005)Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from J. Nat. Prod. 68 564-567
  • [10] Kasai R.(1986)Mollisosides A, B Pure & Appl. Chem. 58 423-436