Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice

被引：0
作者：
Sukchan Lee
Touqeer Ahmed
Soojung Lee
Huisu Kim
Sukwoo Choi
Duk-Soo Kim
Sang Jeong Kim
Jeiwon Cho
Hee-Sup Shin
机构：
[1] Brain Science Institute,Department of Physiology
[2] Korea Institute of Science and Technology,Department of Neuroscience
[3] Seoul National University College of Medicine,Department of Anatomy
[4] University of Science and Technology,undefined
[5] School of Biological Sciences,undefined
[6] College of Natural Sciences,undefined
[7] Seoul National University,undefined
[8] College of Medicine,undefined
[9] Soonchunhyang University,undefined
来源：
Nature Neuroscience | 2012年 / 15卷
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摘要：
The mediodorsal thalamus links the medial prefrontal cortex and the amygdala in associative learning process in primates. Using mouse models, this study finds that the dual firing modes of mediodorsal thalamus neurons, tonic and bursting, have opposite effects on fear extinction.
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页码：308 / 314
页数：6
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共 94 条
  • [1] Ray JP(1992)The organization of the thalamocortical connections of the mediodorsal thalamic nucleus in the rat, related to the ventral forebrain-prefrontal cortex topography J. Comp. Neurol. 323 167-197
  • [2] Price JL(1993)The organization of projections from the mediodorsal nucleus of the thalamus to orbital and medial prefrontal cortex in macaque monkeys J. Comp. Neurol. 337 1-31
  • [3] Ray JP(2005)The neuroscience of mammalian associative learning Annu. Rev. Psychol. 56 207-234
  • [4] Price JL(2004)New vistas on amygdala networks in conditioned fear J. Neurophysiol. 92 1-9
  • [5] Fanselow MS(2000)Neuropsychology of infarctions in the thalamus: a review Neuropsychologia 38 613-627
  • [6] Poulos AM(2003)Involvement of the mediodorsal thalamic nucleus in mediating recollection and familiarity Neuropsychologia 41 1160-1170
  • [7] Paré D(2005)Dissociable memory effects after medial thalamus lesions in the rat Eur. J. Neurosci. 22 973-985
  • [8] Quirk GJ(2008)The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval J. Neurosci. 28 258-263
  • [9] Ledoux JE(1998)Neurotoxic lesions of the dorsomedial thalamus impair the acquisition but not the performance of delayed matching to place by rats: a deficit in shifting response rules J. Neurosci. 18 10045-10052
  • [10] Van der Werf YD(1990)Anterograde and retrograde amnesia in rats with dorsal hippocampal or dorsomedial thalamic lesions Behav. Brain Res. 38 145-154
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