Detection of glutathione based on MnO2 nanosheet-gated mesoporous silica nanoparticles and target induced release of glucose measured with a portable glucose meter

被引：0
作者：
Qingqing Tan
Ruirui Zhang
Rongmei Kong
Weisu Kong
Wenzhi Zhao
Fengli Qu
机构：
[1] Qufu Normal University,College of Chemistry and Chemical Engineering
[2] Chinese Academy of Sciences,Beijing Key Laboratory of Ionic Liquids Clean Process, Key Laboratory of Green Process and Engineering, Institute of Process Engineering
来源：
Microchimica Acta | 2018年 / 185卷
关键词：
MnO; nanosheets; Mesoporous silica; Personal glucose meter; Glutathione; Portable detection; Target induced release;
D O I：
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中图分类号：
学科分类号：
摘要：
The authors describe a novel method for the determination of glutathione (GSH). Detection is based on target induced release of glucose from MnO2 nanosheet-gated aminated mesoporous silica nanoparticles (MSNs). In detail, glucose is loaded into the pores of MSNs. Negatively charged MnO2 nanosheets are assembled on the MSNs through electrostatic interactions. The nanosheets are reduced by GSH, and this results in the release of glucose which is quantified by using a commercial electrochemical glucose meter. GSH can be quantified by this method in the 100 nM to 10 μM concentration range, with a 34 nM limit of detection.
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