Glial reaction of the subventricular zone of the telencephalon of the rat brain on modeling of Alzheimer's disease

被引：0
作者：
E. I. Chumasov
D. E. Korzhevskii
E. S. Petrova
N. N. Kuznetsova
N. S. Sapronov
机构：
[1] Department of General and Special Morphology, Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg
[2] Department of Neuropharmacology, Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg
来源：
Neuroscience and Behavioral Physiology | 2012年 / 42卷 / 1期
基金：
俄罗斯基础研究基金会;
关键词：
Alzheimer's disease; astrocytes; beta-amyloid peptide; brain; subventricular zone;
D O I：
10.1007/s11055-011-9535-1
中图分类号：
学科分类号：
摘要：
The aim of the present work was to study reactive changes in the subventricular zone (SVZ) of the lateral ventricles in the brain in rats at long time points after intraventricular administration of a neurotoxic substance, aggregated beta-amyloid peptide (BAP). At three months, ependymal cells in the SVZ responded to intraventricular administration of BAP by forming a characteristic gliotic structure similar to amyloid plaques in terms of composition, cell structures, and, probably, mechanism of formation. The atypical morphogenesis of these structures is suggested to result from the relationship between degenerative and regenerative processes involving both ependymal cells and progenitor cells of the proliferative zone of the telencephalon. © 2011 Springer Science+Business Media, Inc.
引用
收藏
页码：67 / 71
页数：4
相关论文
共 22 条
  • [1] Beryozov T.T., Kudinova N.V., Kudinov A.R., The role of alzheimer amyloid plaques in the mechanisms of neuron synaptic plasticity disturbance, Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, 10, pp. 3-7, (2005)
  • [2] Grigorenko A.P., Rogaev E.I., Molecular basis of Alzheimer's disease, Molecular Biology, 41, 2, pp. 294-307, (2007)
  • [3] Dudkin K.N., Chueva I.V., Makarov F.N., Et al., Impairment of learning and memory processes in a model of Alzheimer's disease in monkeys: Role of the associative areas of the cerebral cortex, Ros. Fiziol. Zh., 91, 8, pp. 857-871, (2005)
  • [4] Kirik O.V., Sukhorukova E.G., Korzhevskii D.E., calcium-binding protein Iba-1/AIF1 in rat brain cells, Morfologiya, 137, 2, pp. 5-8, (2010)
  • [5] Kokanova N.A., Mikhailova G.Z., Rsh S., Et al., Morphofunctional changes in Mauthner neurons in the goldfish after application of β-amyloid, Morfologiya, 136, 6, pp. 43-48, (2009)
  • [6] Korzhevskii D.E., Use of monoclonal antibodies to nuclear protein PCNA for the detection of proliferating cells in the developing human brain, Morfologiya, 118, 5, pp. 68-70, (2000)
  • [7] Korzhevskii D.E., Grigoriev I.P., Otellin V.A., Use of dehydrating fixatives containing zinc salts in neurohistological studies, Morfologiya, 129, 1, pp. 85-86, (2006)
  • [8] Korzhevskii D.E., Lentsman M.V., Gilyarov A.V., Et al., Morphological signs of local functional activation of astrocytes induced by short-term total cerebral ischemia, Zh. Evolyuts. Biokhim., 43, 5, pp. 423-426, (2007)
  • [9] Korzhevskii D.E., Otellin V.A., Grigoriev I.P., Et al., Structural organization of rat hippocampal astrocytes during the post-ischemic period, Morfologiya, 125, 2, pp. 19-21, (2004)
  • [10] Kostanyan I.A., Zhokhov S.S., Storozheva Z.I., Et al., Neuroprotective effects of the hexapeptide HLDF-6 on rat hippocampal neurons in in vivo and in vitro models of Alzheimer's disease, Bioorgan. Khim., 32, 4, pp. 399-407, (2006)
123