High-resolution computed tomography of the chest in children with cystic fibrosis: support for use as an outcome surrogate

被引：0

作者：

Alan S. Brody

Paul L. Molina

Jeffrey S. Klein

Brian S. Rothman

Maya Ramagopal

Donald R. Swartz

机构：

[1] Departments of Radiology and Pediatrics,

[2] Children's Hospital Medical Center,undefined

[3] Cincinnati,undefined

[4] Ohio,undefined

[5] USA,undefined

[6] University of Cincinnati School of Medicine,undefined

[7] Children's Hospital Medical Center,undefined

[8] Cincinnati,undefined

[9] Ohio,undefined

[10] USA,undefined

[11] Department of Radiology,undefined

[12] 3333 Burnet Ave.,undefined

[13] Cincinnati,undefined

[14] OH 45229–3014,undefined

[15] USA,undefined

[16] Department of Radiology,undefined

[17] University of North Carolina at Chapel Hill,undefined

[18] North Carolina,undefined

[19] USA,undefined

[20] Department of Radiology,undefined

[21] University of Vermont,undefined

[22] Burlington,undefined

[23] Vermont,undefined

[24] USA,undefined

[25] Department of Pediatrics,undefined

[26] University of Vermont,undefined

[27] Burlington,undefined

[28] Vermont,undefined

[29] USA,undefined

来源：

Pediatric Radiology | 1999年 / 29卷

关键词：

Compute Tomography; Cystic Fibrosis; Effective Therapy; Specific Criterion; Patient Benefit;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Background. Outcome surrogates are indicators that reflect, rather than directly measure, patient benefit. In order to provide useful results, however, outcome surrogates must be carefully chosen and must meet specific criteria. Objective. To support development of high-resolution computed tomography (HRCT) as an outcome surrogate in cystic fibrosis (CF) by demonstrating the ability of HRCT to show short-term improvement in the appearance of the lungs in children with CF. Materials and methods. HRCT was performed at admission and after discharge on 8 children during 15 admissions for acute pulmonary exacerbation of CF. Three radiologists scored each study separately, then compared admission and discharge pairs. Results. HRCT scores improved in 13/15 admissions. Mean score decreased from 25 to 22. The decrease was significant (P = 0.014). Comparison of admission and discharge scans showed improvement in peribronchial thickening (P = 0.007), mucous plugging (P = 0.002), and overall appearance (P = 0.025). Conclusion. HRCT has the potential to be a useful outcome surrogate in CF. A necessary attribute of an outcome surrogate is that it improves rapidly with effective therapy. Despite widespread belief among radiologists and pulmonologists that HRCT meets this criterion, no previous report has demonstrated this ability in children. These findings support further development of HRCT as an outcome surrogate in children with CF.

引用

页码：731 / 735

页数：4