Mitochondrial genome and longevity

被引：0
作者：
R. A. Zinovkin
M. V. Skulachev
V. P. Skulachev
机构：
[1] Lomonosov Moscow State University,
[2] Belozersky Institute of Physico-Chemical Biology,undefined
[3] Lomonosov Moscow State University,undefined
[4] Institute of Mitoengineering,undefined
来源：
Biochemistry (Moscow) | 2016年 / 81卷
关键词：
mitochondria; mitochondrial DNA; nuclear genome; lifespan; aging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The mitochondrial genome provides not only respiratory chain function, but it also ensures the impact of mitochondria on nearly all crucial metabolic processes. It is well known that mitochondria regulate aging and lifespan. However, until now there were no direct experimental data concerning the influence of various mitochondrial DNA variants on lifespan of animals with identical nuclear genome. In a recent paper of J. A. Enriquez and coworkers (Latorre-Pellicer, A., et al. (2016) Nature, 535, 561-565), it was shown that mice carrying nuclear DNA from one strain and mitochondrial DNA from another had longer median lifespan and retarded development of various aging traits. This review critically analyzes that paper and considers some aspects of the crosstalk between the nuclear and mitochondrial genomes. We also discuss new perspectives of gerontology in the light of the discovery made by Enriquez’s group.
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页码：1401 / 1405
页数：4
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