Stimulus properties of fluvoxamine in a conditioned taste aversion procedure

被引：0

作者：

J. Gommans

J. A. Bouwknecht

T. H. Hijzen

H. H. G. Berendsen

C. L. E. Broekkamp

R. A. A. Maes

B. Olivier

机构：

[1] Department of Psychopharmacology,

[2] Faculty of Pharmacy,undefined

[3] Utrecht University,undefined

[4] Sorbonnelaan 16,undefined

[5] 3584 CA Utrecht,undefined

[6] The Netherlands e-mail: T.H. Hijzen @ PHARM.UU.NL,undefined

[7] Fax: +31-30-253-7387,undefined

[8] Department of Neuropharmacology,undefined

[9] N.V. Organon,undefined

[10] Oss,undefined

[11] The Netherlands,undefined

[12] Department of Toxicology,undefined

[13] Faculty of Pharmacy,undefined

[14] Utrecht University,undefined

[15] Utrecht,undefined

[16] The Netherlands,undefined

来源：

Psychopharmacology | 1998年 / 140卷

关键词：

Key words Serotonin (5-HT) reuptake inhibitor; Fluvoxamine; Fluoxetine; Stimulus properties; Conditioned taste aversion; 5-HT1A receptor; 5-HT2C receptor;

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摘要：

A conditioned taste aversion (CTA) procedure in mice was used to investigate the stimulus effects of the serotonin reuptake inhibitors (SSRIs) fluvoxamine and fluoxetine. Fluvoxamine elicited a reliable CTA (ED50 = 24 mg/kg, SC) and a number of drugs were tested as pre-exposure drugs. Pre-exposure to the serotonin (5-HT)1A receptor agonists flesinoxan and ±-8-hydroxy-dipropylaminotetralin (8-OH-DPAT) prevented the CTA induced by fluvoxamine (50 mg/kg, SC). Pre-exposure with the 5-HT2C receptor agonist MK 212 [6-chloro-2(1-piperazinyl)pyrazine] partially prevented the fluvoxamine-induced CTA, pre-exposure with the 5-HT2A/2C receptor agonist DOI [1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl] did not prevent the CTA induced by fluvoxamine. Flesinoxan pre-exposure also prevented the taste aversion induced by fluoxetine (10 mg/kg, SC) completely. This contrasts previous results obtained with fluoxetine, where was found that its stimulus is primarily mediated by 5-HT2C, and to a lesser degree by 5-HT1A receptors. Therefore, we compared the two SSRIs directly. Pre-exposure to fluvoxamine prevented the fluoxetine-induced CTA, whereas pre-exposure to fluoxetine only partially prevented the fluvoxamine-induced CTA. We conclude that 5-HT1A receptors are involved in the stimulus properties of both fluvoxamine and fluoxetine, that 5-HT2C receptors are involved in fluvoxamine and especially fluoxetine, and , based primarily on the cross-comparison tests, that the two SSRIs have somewhat different stimulus properties.

引用

页码：496 / 502

页数：6