Cellular Effects of Progranulin in Health and Disease

被引：0
作者：
Louis De Muynck
Philip Van Damme
机构：
[1] VIB,Vesalius Research Center
[2] K.U. Leuven,Laboratory of Neurobiology
[3] K.U. Leuven,Department of Neurology
[4] University Hospital Leuven,Department of Neurology
来源：
Journal of Molecular Neuroscience | 2011年 / 45卷
关键词：
Progranulin; Microglia; Frontotemporal degeneration; Inflammation; Tumorigenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Progranulin is a fascinating multifunctional protein, which has been implicated in cell growth, wound repair, tumorigenesis, inflammation, neurodevelopment, and more recently in neurodegeneration. The mechanism of action of this protein is still largely unknown, but the knowledge about the cellular effects on various cell types is expanding. In the current review, we will summarize what is known about the cell biology of progranulin. A better understanding of the biology of progranulin will impact diverse areas of research.
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页码：549 / 560
页数：11
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