Synthesis of novel polyfunctional pyrrolo[2,1-a]isoquinolines based on 1,3-dipolar cycloaddition reactions

被引：0
|
作者：
M. A. Bastrakov
A. M. Starosotnikov
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
来源：
Russian Chemical Bulletin | 2019年 / 68卷
关键词：
pyrrolo[2,1-; ]isoquinoline; nitro compounds; [3+2] cycloaddition; nucleophilic substitution;
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学科分类号：
摘要：
A series of 5-substituted 8-nitroisoquinolines was synthesized based on the reaction of 5-bromo-8-nitroisoquinohne with various nucleophiles. N-Alkylation products of 8-nitroisoquinolines were shown to undergo 1,3-dipolar cycloaddition to substituted alkenes and alkynes as dipolarophiles in the presence of a base to form new polyfunctional nitro-containing pyrrolo-[2,1-a]isoquinolines and their hydrogenated analogs.
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页码：1729 / 1734
页数：5
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