HIV-1 drug-resistance and drug-dependence

被引：0
作者：
Chris Baldwin
Ben Berkhout
机构：
[1] Academic Medical Center of the University of Amsterdam,Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA)
来源：
Retrovirology | / 4卷
关键词：
Enfuvirtide; Fusion Inhibitor; Conformational Switch; I37K Mutation; S138A Change;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this review, we will describe several recent HIV-1 studies in which a drug-dependent virus variant was selected. A common evolutionary route to the drug-dependence phenotype is proposed. First, the selection of a drug-resistance mutation that also affects the function of the targeted viral protein. Second, a compensatory mutation that repairs the protein function, but in the presence of the drug, which becomes an intrinsic part of the mechanism. The clinical relevance of drug-dependent HIV-1 variants is also discussed.
引用
收藏
相关论文
共 244 条
[1]  
Baldwin CE(2004)Emergence of a drug-dependent human immunodeficiency virus type 1 variant during therapy with the T20 fusion inhibitor J Virol 78 12428-12437
[2]  
Sanders RW(2003)Processivity and drug-dependence of HIV-1 protease: determinants of viral fitness in variants resistant to protease inhibitors AIDS 17 663-671
[3]  
Deng Y(1997)Atomic structure of the ectodomain from HIV-1 gp41 Nature 387 426-430
[4]  
Jurriaans S(1997)Atomic structure of a thermostable subdomain of HIV-1 gp41 Proc Natl Acad Sci USA 94 12303-12308
[5]  
Lange JM(1997)Core structure of gp41 from the HIV envelope glycoprotein Cell 89 263-273
[6]  
Lu M(1995)A trimeric structural domain of the HIV-1 transmembrane glycoprotein Nat Struct Biol 2 1075-1082
[7]  
Berkhout B(1994)Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection Proc Natl Acad Sci USA 91 9770-9774
[8]  
Menzo S(1994)Functional role of the zipper motif region of human immunodeficiency virus type 1 transmembrane protein gp41 J Virol 68 2002-2010
[9]  
Monachetti A(2003)Inhibiting HIV-1 entry with fusion inhibitors Curr Med Chem 10 1633-1642
[10]  
Balotta C(2004)Resistance to enfuvirtide, the first HIV fusion inhibitor J Antimicrob Chemother 54 333-340
12345678910