Laser flare photometry: A noninvasive, objective, and quantitative method to measure intraocular inflammation

被引:108
作者
Tugal-Tutkun I. [1 ]
Herbort C.P. [2 ]
机构
[1] Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, Istanbul
[2] Inflammatory Eye Diseases, Center for Specialized Ophthalmic Care, Lausanne
关键词
Aqueous cells; Aqueous flare; Intraocular inflammation; Laser flare cell photometry; Laser flare photometry; Uveitis;
D O I
10.1007/s10792-009-9310-2
中图分类号
学科分类号
摘要
Aqueous flare and cells are the two inflammatory parameters of anterior chamber inflammation resulting from disruption of the blood-ocular barriers. When examined with the slit lamp, measurement of intraocular inflammation remains subjective with considerable intra- and interobserver variations. Laser flare cell photometry is an objective quantitative method that enables accurate measurement of these parameters with very high reproducibility. Laser flare photometry allows detection of subclinical alterations in the blood-ocular barriers, identifying subtle pathological changes that could not have been recorded otherwise. With the use of this method, it has been possible to compare the effect of different surgical techniques, surgical adjuncts, and anti-inflammatory medications on intraocular inflammation. Clinical studies of uveitis patients have shown that flare measurements by laser flare photometry allowed precise monitoring of well-defined uveitic entities and prediction of disease relapse. Relationships of laser flare photometry values with complications of uveitis and visual loss further indicate that flare measurement by laser flare photometry should be included in the routine follow-up of patients with uveitis. © 2009 Springer Science+Business Media B.V.
引用
收藏
页码:453 / 464
页数:11
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共 59 条
[1]  
Tyndall J., On the blue of the sky, the polarization of the skylight, and on the polarization of light by cloudy matter generally, Philos Mag J Sci, 37, pp. 384-404, (1869)
[2]  
Hogan M.J., Kimura S.J., Thygeson P., Signs and symptoms of uveitis. I. Anterior uveitis, Am J Ophthalmol, 47, pp. 155-170, (1959)
[3]  
Thorne J.E., Jabs D.A., Peters G.B., Hair D., Dunn J.P., Kempen J.H., Birdshot retinochoroidopathy: Ocular complications and visual impairment, American Journal of Ophthalmology, 140, 1, (2005)
[4]  
Spalton D.J., Ocular fluorophotometry, Br J Ophthalmol, 74, pp. 431-432, (1990)
[5]  
Johnstone McLean N.S., Ward D.A., Hendrix D.V.H., The effect of a single dose of topical 0.005% latanoprost and 2% dorzolamide/0.5% timolol combination on the blood-aqueous barrier in dogs: A pilot study, Veterinary Ophthalmology, 11, 3, pp. 158-161, (2008)
[6]  
Waterbury L.D., Flach A.J., Comparison of ketorolac tromethamine, diclofenac sodium, and loteprednol etabonate in an animal model of ocular inflammation, Journal of Ocular Pharmacology and Therapeutics, 22, 3, pp. 155-159, (2006)
[7]  
Sawa M., Tsurimaki Y., Tsuru T., Shimizu H., New quantitative method to determine protein concentration and cell number in aqueous in vivo, Jpn J Ophthalmol, 32, pp. 132-142, (1988)
[8]  
Shah S.M., Spalton D.J., Taylor J.C., Correlations between laser flare measurements and anterior chamber protein concentrations, Invest Ophthalmol Vis Sci, 33, pp. 2878-2884, (1992)
[9]  
Shah S.M., Spalton D.J., Smith S.E., Measurement of aqueous cells and flare in normal eyes, Br J Ophthalmol, 75, pp. 348-352, (1991)
[10]  
El-Maghraby A., Marzouki A., Matheen T.M., Souchek J., Van Der Karr M., Reproducibility and validity of laser flare/cell meter measurement as an objective method of assessing intraocular inflammation, Arch Ophthalmol, 110, pp. 960-962, (1992)