Electroacupuncture Effects in a Rat Model of Complete Freund’s Adjuvant-Induced Inflammatory Pain: Antinociceptive Effects Enhanced and Tolerance Development Accelerated

被引：0
作者：
Cheng Huang
Zhi-Qin Huang
Zhi-Ping Hu
Shao-Zu Jiang
Han-Ting Li
Ji-Sheng Han
You Wan
机构：
[1] Gannan Medical University,Department of Physiology
[2] Peking University,Neuroscience Research Institute
[3] Gannan Medical University,Department of Pharmacy
来源：
Neurochemical Research | 2008年 / 33卷
关键词：
Electroacupuncture; Antinociception; Complete Freund’s adjuvant; Inflammatory pain; Tolerance; Naloxone;
D O I：
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中图分类号：
学科分类号：
摘要：
We have previously shown that electroacupuncture (EA) produced antinociception through the release of endogenous opioid peptides to activate opioid receptors during acute nociception. EA produced tolerance after its prolonged application. It has reported that 100 Hz EA could reduce mechanical hyperalgesia in complete Freund’s adjuvant (CFA)-induced inflammatory nociception rats. The present study aims to investigate the antinociceptive effect of EA and the development of EA tolerance in chronic inflammatory nociception rats with CFA injection into the hind paw plantar. The results showed that the antinociceptive effect of 100 Hz EA was significantly enhanced in CFA-induced inflammatory nociception rats. Naloxone at 20 mg/kg could significantly block this antinociceptive effect. Chronic tolerance to EA was developed faster in CFA-induced inflammatory nociception rats than in normal rats. Therefore, 100 Hz EA could enhance antinociceptive effects and accelerate tolerance development in CFA-induced inflammatory nociception rats. The enhancement of EA antinociceptive effect in CFA-induced inflammatory nociception rats might involve the endogenous opioid peptides such as dynorphin.
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页码：2107 / 2111
页数：4
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