Childhood B-acute lymphoblastic leukemia: A genetic update

被引：93
作者：
Woo J.S. [1 ]
Alberti M.O. [1 ]
Tirado C.A. [1 ]
机构：
[1] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, 1010 Veteran Ave
来源：
Experimental Hematology & Oncology | / 3卷 / 1期
关键词：
B-cell; B-precursor; Cytogenetics; Genetics; Pediatric B-ALL;
D O I：
10.1186/2162-3619-3-16
中图分类号：
学科分类号：
摘要：
In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy, as well as the leading cause of childhood cancer-related mortality. Advances in cytogenetics utilizing array-based technologies and next-generation sequencing (NGS) techniques have revealed exciting insights into the genetic basis of this disease, with the hopes of developing individualized treatment plans for affected children. In this comprehensive review, we discuss our current understanding of childhood (pediatric) B-ALL and highlight the most recent genetic advances and their therapeutic implications. © 2014 Woo et al.; licensee BioMed Central Ltd.
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