Dihydroquercetin Does Not Affect Age-Dependent Increase in Blood Pressure and Angiotensin-Converting Enzyme Activity in the Aorta of Hypertensive Rats

被引：0
作者：
G. A. Slashcheva
V. A. Rykov
A. V. Lobanov
A. N. Murashev
Yu. A. Kim
T. V. Arutyunyan
A. F. Korystova
L. N. Kublik
M. Kh. Levitman
V. V. Shaposhnikona
Yu. N. Korystov
机构：
[1] Russian Academy of Sciences,Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
[2] Russian Academy of Sciences,Institute of Cell Biophysics
[3] Russian Academy of Sciences,Institute of Theoretical and Experimental Biophysics
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 161卷
关键词：
angiotensin-converting enzyme; aorta; dihydroquercetin; hypertension; SHR;
D O I：
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摘要：
We analyzed changes in angiotensin-converting enzyme activity in the aorta of hypertensive SHR rats against the background of age-related BP increase (from week 7 to 14) and the effect of dihydroquercetin on BP rise and angiotensin-converting enzyme activity. Normotensive WKY rats of the same age were used as the control. BP and activity of angiotensin-converting enzyme in the aorta of SHR rats increased with age. Dihydroquercetin in doses of 100 and 300 μg/kg per day had no effect on the increase of these parameters; dihydroquercetin administered to 14-week-old WKY rats in a dose of 300 μg/kg reduced activity of the angiotensin-converting enzyme. Thus, the early (7-14 weeks) increase in BP and angiotensin-converting enzyme activity in the aorta of SHR rats was not modified by flavonoids (dihydroquercetin) in contrast to other rat strains and humans, which is indicative of specificity of hypertension mechanism in SHR rats.
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页码：670 / 673
页数：3
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共 39 条
  • [1] Ackermann A(1998)Modulation of angiotensin-converting enzyme by nitric oxide Br. J. Pharmacol. 124 291-298
  • [2] Fernández-Alfonso MS(2000)Matrix gene expression and decompensated heart failure: the aged SHR model Cardiovasc. Res. 46 239-249
  • [3] Sánchez de Rojas R(2007)A quercetin supplemented diet does not prevent cardiovascular complications in spontaneously hypertensive rats J. Nutr. 137 628-633
  • [4] Ortega T(2000)International union of pharmacology. XXIII. The angiotensin II receptors Pharmacol. Rev. 52 415-472
  • [5] Paul M(2001)Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats Br. J. Pharmacol. 133 117-124
  • [6] González C(2010)Flavonoids: antioxidants against atherosclerosis Nutrients 2 889-902
  • [7] Boluyt MO(2011)Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats Am. J. Physiol. Renal. Physiol. 300 F499-F510
  • [8] Bing OH(2000)Flavonoids for reduction of atherosclerotic risk Curr. Atheroscler. Rep. 6 73-78
  • [9] Carlstrom J(2002)Cranberry flavonoids, atherosclerosis and cardiovascular health Crit. Rev. Food Sci. Nutr. 42 301-316
  • [10] Symons JD(undefined)undefined undefined undefined undefined-undefined
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