Synthesis and antimicrobial evaluation of new glucosylimino thiazole derivatives

被引：0
作者：
Amira A. Ghoneim
Ahmed F. El-Farargy
机构：
[1] Jouf University,Chemistry Department, College of Science
[2] Zagazig University,Chemistry Department, Faculty of Science
来源：
Journal of the Iranian Chemical Society | 2019年 / 16卷
关键词：
Synthesis; Antimicrobial; Glucosylimino; Thiazole derivatives;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
p-Sulphonic-N-propionyl aniline 3 was produced from sulphanilic acid with propionic acid under reflux for 2 h, then the compound 3 reacted with thionyl chloride and the corresponding imidoyl chloride 4 was obtained. When imidoyl chloride 4 reacted with potassium isothiocyanate and aniline, the corresponding thiourea derivatives 6 was produced. Compound 6 was reacted with tricyanovinylamine to produce the thiazole derivative 7 after cyclization. The microwave-assisted condensation of 2,3,4.6,-tetra-O-acetyl-β-D-glucopyranosylisothiocynate 8 with thiazole derivative 7 afforded the thiourea derivatives 9. Compound 10 a, b has been synthesized by reacting thiourea derivatives 9 with chloroacetone. The prepared compounds were screened for antibacterial properties against Staphylococcus aureus and Escherichia coli, and antifungal activity against Candida sp. The structure assignments of the new synthesized compounds are based on spectroscopic data.
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页码：1391 / 1399
页数：8
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