Molecular genetics and migraine

被引：1

作者：

Pasquale Montagna

机构：

[1] Institute of Clinical Neurology,

[2] University of Bologna Medical School,undefined

[3] Via U. Foscolo 7,undefined

[4] I-40123 Bologna,undefined

[5] Italy,undefined

[6] e-mail: pmontagn@neuro.unibo.it,undefined

[7] Tel.: +39-051-6442179,undefined

[8] Fax: +39-051-6442165,undefined

来源：

The Journal of Headache and Pain | 2000年 / 1卷 / Suppl 2期

关键词：

Key words Migraine; Headache; Genetics; Serotonin; Dopamine; Mitochondria;

D O I：

10.1007/s101940070007

中图分类号：

学科分类号：

摘要：

Migraine carries a significant hereditary determination. Familial hemiplegic migraine (FHM) has been recently linked to mutations in the CACNA1A gene on chromosome 19. CACNA1A codes for a subunit of a neural calcium channel. Other linkage loci on chromosome 1q21-23 and 1q31 have been reported. Several linkage and association studies have been performed to determine the role of the CACNA1A gene, and of other candidate genes implicated in the metabolism of serotonin and dopamine, in the more common types of migraine. Co-morbidity of migraine with vascular events has been analysed versus genetic prothrombotic factors and mitochondrial DNA, and genes involved in the inflammatory cascade have been explored. Though no definite conclusions have emerged from these studies as yet, molecular genetics of migraine can be expected to unravel the complex aetiologies of these fascinating diseases.

引用

页码：S135 / S140