pH-controlled drug release of radiation synthesized graphene oxide/(acrylic acid-co-sodium alginate) interpenetrating network

被引：0
作者：
Amany Ismael Raafat
Amr El-Hag Ali
机构：
[1] National Center for Radiation Research and Technology,Polymer Chemistry Department
[2] Atomic Energy Authority,undefined
来源：
Polymer Bulletin | 2017年 / 74卷
关键词：
Alginate; Graphene oxide; Swelling characteristics; Drug delivery systems; Biocomposites;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hydrogel biocomposites containing a combination of graphene oxide (GO) and natural polymer-based copolymer of sodium alginate (Alg) and acrylic acid (AAc) were prepared by radiation-induced copolymerization and crosslinking. FTIR, XRD, and AFM analyses revealed the successful preparation of single-layered graphene oxide sheets. FTIR and TGA data confirmed the incorporation of GO within the (AAc-co-Alg) copolymer hydrogel. The effect of GO content, as interpenetrating network, on the swelling behavior of (AAc-co-Alg) copolymer hydrogel was investigated. The results of the pH-dependent swelling showed the presence of GO within the prepared hydrogel improve the ability of the GO/(AAc-co-Alg) nanocomposite hydrogel to bypass the acidity of the simulated stomach medium (pH 1) without significant swelling and regulate it for longer period in simulated intestine medium (pH 7). Moreover, the swelling kinetics showed that all the samples under investigation possess Fickian at pH 1 and non-Fickian at pH 7. The evaluation of the prepared GO/(AAc-co-Alg) nanocomposite hydrogel as drug carrier was carried out in either simulated stomach and intestine media using cefadroxil as a model drug. The drug release profile came in a good agreement with swelling results which recommend the GO/(AAc-co-Alg) nanocomposite hydrogel as potential targeted drug delivery system.
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页码：2045 / 2062
页数：17
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  • [11] Reddy KR(2014)Graphene modified lipophilically by stearic acid and its composite with low density polyethylene J Macromol Sci Part B 53 1193-1204
  • [12] Lee H-I(2006)Synthesis and electrical response of acrylic acid/vinyl sulfonic acid hydrogels prepared by γ-irradiation Radiat Phys Chem 75 1041-1046
  • [13] Yoon KS(2005)Radiation synthesis of interpolymer polyelectrolyte complex and its application as a carrier for colon-specific drug delivery system Biomaterials 26 2733-2739
  • [14] Jeong HM(2015)The use of a hydrogel matrix for controlled delivery of niacin to the gastrointestinal tract for treatment of hyperlipidemia Physiol Res/Academia Scientiarum Bohemoslovaca 64 S51-S60
  • [15] Kim BK(2006)Thermo- and pH-responsive polymers in drug delivery Adv Drug Deliv Rev 58 1655-1670
  • [16] Puri P(2009)Characterization and in vitro evaluation of starch based hydrogels as carriers for colon specific drug delivery systems Carbohydr Polym 78 725-730
  • [17] Mehta R(2010)Gelatin based pH-sensitive hydrogels for colon-specific oral drug delivery: synthesis, characterization, and in vitro release study J Appl Polym Sci 118 2642-2649
  • [18] Rattan S(2008)Synthesis of carboxymethyl cellulose based drug carrier hydrogel using ionizing radiation for possible use as site specific delivery system J Macromol Sci Part A 45 628-634
  • [19] Zhou Q(2014)Controlled release of anticancer drug using graphene oxide as a drug-binding effector in konjac glucomannan/sodium alginate hydrogels Colloids Surf B 113 223-229
  • [20] Ye X(2015)Polymeric micelles and nanoemulsions as tumor-targeted drug carriers: insight through intravital imaging J Controll Releas 206 153-160
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