Therapy for Menopausal Symptoms During and After Treatment for Breast CancerSafety Considerations

被引:0
作者
Rodney Baber
Martha Hickey
Michelle Kwik
机构
[1] Royal North Shore Hospital of Sydney,Division of Women’s and Children’s Health
[2] The University of Sydney,School of Women’s and Infants’ Health, King Edward Memorial Hospital Perth
[3] The University of Western Australia,undefined
来源
Drug Safety | 2005年 / 28卷
关键词
Breast Cancer; Tamoxifen; Hormone Therapy; Breast Cancer Survivor; Mammographic Density;
D O I
暂无
中图分类号
学科分类号
摘要
Breast cancer is the most common newly diagnosed cancer in women. Life-time risk in the US is 1 in 8 (13.2%), in the UK it is 1 in 9 and in Australia it affects 1 in 11 women, of whom approximately 27% will be premenopausal at the time of their diagnosis. Many of these women will experience a sudden menopause as a result of chemotherapy, endocrine therapy or surgical interventions. For these women, the onset of menopausal symptoms is often sudden and severe. The management of such symptoms remains controversial. Women experiencing menopausal symptoms after breast cancer should be encouraged to avoid identifiable triggers for their symptoms and to consider lifestyle modification as a means of controlling those symptoms. When such measures fail, non-hormonal treatments may also be considered. These include clonidine, gabapentin and some antidepressants. Randomised trials have shown a significant difference in the symptom relief associated with various selective serotonin reuptake inhibitors and selective serotonin and noradrenaline (norepinephrine) reuptake inhibitors compared with placebo. Many women elect to use non-prescription complementary therapies to alleviate their menopausal symptoms. Systematic reviews of phytoestrogens have, however, failed to demonstrate significant relief of menopausal symptoms.
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页码:1085 / 1100
页数:15
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