Dimethylarginines and inflammation markers in patients with chronic kidney disease undergoing dialysis

被引：0
作者：
Yildiz Oner-Iyidogan
Pernur Oner
Hikmet Kocak
Figen Gurdol
Seldag Bekpinar
Yesim Unlucerci
Yasar Caliskan
Pinar Cetinalp-Demircan
Taner Kocak
Aydin Turkmen
机构：
[1] Istanbul University,Medical Laboratory Programme, Medical Services Training School
[2] Istanbul University,Department of Biochemistry, Istanbul Faculty of Medicine
[3] Istanbul University,Department of Nephrology
[4] Istanbul University,Department of Urology
来源：
Clinical and Experimental Medicine | 2009年 / 9卷
关键词：
ADMA; SDMA; Chronic kidney disease; Inflammation; Dimethylarginines; Dialysis;
D O I：
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中图分类号：
学科分类号：
摘要：
The aim of this study was to investigate the pro-oxidant and proinflammatory biomarkers and their relationship with dimethylarginines (DMAs) in patients at various stages of chronic kidney disease (CKD). We studied 114 CKD patients, 36 were hemodialyzed, 41 peritoneal dialyzed and 37 nondialyzed (early stage) CKD patients. The control group consisted of 31 healthy subjects. Plasma levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), l-arginine, nitric oxide (NO) and proinflammatory cytokines (TNF-alpha and IL-6) were determined, and their relationships with the degree of disease were evaluated. Both DMAs were at high levels in all CKD patients, whereas arginine concentrations were low in patients undergoing dialysis. Elevated TNF-α and IL-6 in CKD patients were indicative of ongoing chronic inflammatory state. A significant positive correlation between SDMA and creatinine suggests that plasma SDMA level may be an index for renal function.
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