Association of diabetes susceptibility gene Calpain-10 with pancreatic cancer among smokers

被引：18

作者：

Fong P.-Y. ^{[1
]}

Fesinmeyer M.D. ^{[3
]}

White E. ^{[2
,3
]}

Farin F.M. ^{[4
]}

Srinouanprachanh S. ^{[4
]}

Afsharinejad Z. ^{[4
]}

Mandelson M.T. ^{[3
,6
]}

Brentnall T.A. ^{[5
]}

Barnett M.J. ^{[3
]}

Goodman G.E. ^{[3
]}

Austin M.A. ^{[1
,2
,3
]}

机构：

[1] Institute for Public Health Genetics, University of Washington, Box 357236, Seattle

[2] Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA

[3] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA

[4] Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA

[5] Department of Medicine, School of Medicine, University of Washington, Seattle, WA

[6] GH Center for Health Studies, Group Health Cooperative, Seattle, WA

来源：

Journal of Gastrointestinal Cancer | 2010年 / 41卷 / 3期

基金：

美国国家卫生研究院;

关键词：

Calpain-10; CAPN10; Diabetes; Pancreatic cancer;

D O I：

10.1007/s12029-010-9130-7

中图分类号：

学科分类号：

摘要：

Objective The objective of this study was to test the association between calpain-10 (CAPN10), a diabetes susceptibility gene, with risk of pancreatic cancer (PC). Methods DNA samples from 83 incident exocrine PC cases and 166 controls, all of whom were smokers, were genotyped for four markers of CAPN10 in a nested case-control study based on the Beta-Carotene and Retinol Efficacy Trial (CARET), a randomized chemoprevention trial of subjects at high risk of lung cancer. Controls were matched on sex, race, age, CARET intervention arm, duration of exposure to asbestos, and smoking history. Conditional logistic regression was used for statistical analyses. Results The minor allele of SNP-43 (rs3792267) in intron 3 was associated with increased risk of PC with an odds ratio of 1.57 (95%CI 1.03-2.38, p = 0.035) per allele. The three markers of the highest risk haplotype had an odds ratio of 1.98 (95%CI 1.12-3.49, p=0.019) for risk of PC compared to the most common haplotype. There was no evidence of interaction between either of these associations by diabetes status. Conclusion These results suggest that variation in CAPN10 may be associated with increased risk of PC among smokers. Thus, studies of genes associated with diabetes risk in PC are warranted in a larger population. © Springer Science+Business Media, LLC 2010.

引用

页码：203 / 208

页数：5

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