TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden

被引：0
作者：
Sofia Mayans
Kurt Lackovic
Petter Lindgren
Karin Ruikka
Åsa Ågren
Mats Eliasson
Dan Holmberg
机构：
[1] Umeå University,Division of Medical and Clinical Genetics, Department of Medical Biosciences
[2] Sunderby Hospital,Department of Medicine
[3] Umeå University,Department of Public Health and Clinical Medicine
来源：
European Journal of Human Genetics | 2007年 / 15卷
关键词：
association; diabetes; polymorphism;
D O I：
暂无
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学科分类号：
摘要：
A recent study found association of one microsatellite and five single nucleotide polymorphisms (SNPs) in intron 3 of the TCF7L2 gene with type 2 diabetes (T2D) in the Icelandic, Danish and American populations. The aim of the present study was to investigate if those SNPs were associated to T2D in two (family- and population-based) cohorts from northern Sweden. We genotyped four of the associated SNPs in a case–control cohort consisting of 872 T2D cases and 857 controls matched with respect to age, sex and geographical origin and in a sample of 59 extended families (148 affected and 83 unaffected individuals). Here, we report replication of association between T2D and three SNPs in the case–control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. This replication strengthens the evidence for involvement of TCF7L2 in T2D.
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页码：342 / 346
页数：4
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共 67 条
[1]  
Malecki MT(2005)Genetics of type 2 diabetes mellitus Diabetes Res Clin Pract 68 S10-S21
[2]  
Parikh H(2004)Candidate genes for type 2 diabetes Rev Endocr Metab Disord 5 151-176
[3]  
Groop L(1996)A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 Nat Genet 13 161-166
[4]  
Hanis CL(1996)Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families Nat Genet 14 90-94
[5]  
Boerwinkle E(1999)A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians Diabetes 48 1175-1182
[6]  
Chakraborty R(2000)Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus Nat Genet 26 163-175
[7]  
Mahtani MM(2006)Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 38 320-323
[8]  
Widen E(2000)The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes Nat Genet 26 76-80
[9]  
Lehto M(1998)Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in Caucasians Diabetologia 41 1511-1515
[10]  
Elbein SC(2003)Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23 K variant is associated with type 2 diabetes Diabetes 52 568-572
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