Epithelial-mesenchymal transition, cancer stem cells and treatment resistance

被引：0
作者：
Bhuvanesh Dave
Vivek Mittal
Nicholas M Tan
Jenny C Chang
机构：
[1] Methodist Hospital Cancer Center,
[2] Weil Cornell Medical School,undefined
来源：
Breast Cancer Research | / 14卷
关键词：
Cancer Stem Cell; Disseminate Tumor Cell; Metanephric Mesenchyme; Breast CSCs; Breast Cancer Relapse;
D O I：
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学科分类号：
摘要：
Breast cancer relapse, in a large number of patients, after initial response to standard of care therapy warrants development of novel therapies against recurrent and metastatic cancer. Cancer stem cells (CSCs), present in breast tumors while being intrinsically resistant to conventional therapy, have the ability to self renew and cause tumor recurrence. The residual tumors after therapy, with dramatic enrichment of the CSCs, have all the hallmarks of epithelial- mesenchymal transition (EMT). This review will focus on the link between EMT, CSCs and treatment resistance, since a better understanding of these interactions will allow us to effectively target the residual population after therapy.
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  • [1] Berry DA(2005)Effect of screening and adjuvant therapy on mortality from breast cancer N Engl J Med 353 1784-1792
  • [2] Cronin KA(2009)Mouse models for human epithelial disease: novel insights and new horizons Exp Physiol 94 169-170
  • [3] Plevritis SK(2005)Patterns of resistance and incomplete response to docetaxel by gene expression profiling in breast cancer patients J Clin Oncol 23 1169-1177
  • [4] Fryback DG(2008)Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy J Natl Cancer Inst 100 672-679
  • [5] Clarke L(2003)Epithelial-mesenchymal transition and its implications for fibrosis J Clin Invest 112 1776-1784
  • [6] Zelen M(1995)An overview of epithelio-mesenchymal transformation Acta Anat (Basel) 154 8-20
  • [7] Mandelblatt JS(2002)Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 442-454
  • [8] Yakovlev AY(2009)Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features Proc Natl Acad Sci USA 106 13820-13825
  • [9] Habbema JD(2003)Expression profiling of epithelial plasticity in tumor progression Oncogene 22 7155-7169
  • [10] Feuer EJ(2003)Mechanisms of TGF-β signaling from cell membrane to the nucleus Cell 113 685-700
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