Epithelial-mesenchymal transition, cancer stem cells and treatment resistance

被引：0
作者：
Bhuvanesh Dave
Vivek Mittal
Nicholas M Tan
Jenny C Chang
机构：
[1] Methodist Hospital Cancer Center,
[2] Weil Cornell Medical School,undefined
来源：
Breast Cancer Research | / 14卷
关键词：
Cancer Stem Cell; Disseminate Tumor Cell; Metanephric Mesenchyme; Breast CSCs; Breast Cancer Relapse;
D O I：
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学科分类号：
摘要：
Breast cancer relapse, in a large number of patients, after initial response to standard of care therapy warrants development of novel therapies against recurrent and metastatic cancer. Cancer stem cells (CSCs), present in breast tumors while being intrinsically resistant to conventional therapy, have the ability to self renew and cause tumor recurrence. The residual tumors after therapy, with dramatic enrichment of the CSCs, have all the hallmarks of epithelial- mesenchymal transition (EMT). This review will focus on the link between EMT, CSCs and treatment resistance, since a better understanding of these interactions will allow us to effectively target the residual population after therapy.
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