Magnetic Nanoparticles as Contrast Agents for Magnetic Resonance Imaging

被引：0
作者：
R. S. Chaughule
S. Purushotham
R. V. Ramanujan
机构：
[1] Ramnarain Ruia College,Energy Research Institute @NTU, Research TechnoPlaza, X
[2] Nanyang Technological University,Frontier Block Level 5, 50 Nanyang Drive
[3] Nanyang Technological University,School of Materials Science and Engineering
来源：
Proceedings of the National Academy of Sciences, India Section A: Physical Sciences | 2012年 / 82卷
关键词：
Magnetic nanoparticles; SPIONs; MRI; MRI contrast agents;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the field of nanotechnology, new magnetic materials such as superparamagnetic iron oxide nanoparticles (NPs) have been developed as novel magnetic resonance imaging (MRI) contrast agents. This is due to their unique properties such as large surface area, biodegradability and superparamagnetic properties. This review article discusses the development of such contrast agents. The effect of relaxation times of magnetic NPs (MNPs) with varying size, surface modification etc. on the development of contrast in MRI is also discussed. Such MNPs are now commercially available because of their safety and high sensitivity.
引用
收藏
页码：257 / 268
页数：11
相关论文
共 382 条
[1]  
Barry SE(2008)Challenges in the development of magnetic particles for therapeutic applications Int J Hyperth 24 451-466
[2]  
Gupta AK(2005)Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications Biomaterials 26 3995-4021
[3]  
Gupta M(1999)Physiological aspects in magnetic drug-targeting J Magn Magn Mater 194 149-155
[4]  
Lübbe AS(1996)Clinical experiences with magnetic drug targeting: a phase I study with 4′-epidoxorubicin in 14 patients with advanced solid tumors Cancer Res 56 4686-4693
[5]  
Bergemann C(2000)Locoregional cancer treatment with magnetic drug targeting Cancer Res 60 6641-6648
[6]  
Brock J(2006)Targeting cancer cells: magnetic nanoparticles as drug carriers Eur Biophys J 35 446-450
[7]  
McClure DG(2006)Drug loaded magnetic nanoparticles for cancer therapy J Phys Condens Matter 18 2893-2902
[8]  
Lübbe AS(2010)Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy Acta Biomater 6 502-510
[9]  
Bergemann C(2011)Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy Adv Drug Deliv Rev 63 24-46
[10]  
Riess H(2010)Modeling the performance of magnetic nanoparticles in multimodal cancer therapy J Appl Phys 107 114701-114706
12345678910