Silica, Alumina and Clay Catalyzed Peptide Bond Formation: Enhanced Efficiency of Alumina Catalyst

被引：0

作者：

Juraj Bujdák

Bernd M. Rode

机构：

[1] Slovak Academy of Sciences,Institute of Inorganic Chemistry

[2] University of Innsbruck,Institute of General, Inorganic and Theoretical Chemistry

来源：

Origins of life and evolution of the biosphere | 1999年 / 29卷

关键词：

Clay; Proline; Dehydration; Leucine; Valine;

D O I：

暂无

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学科分类号：

摘要：

Catalytic efficiencies of clay (hectorite), silica and alumina were tested in peptide bond formation reactions of glycine (Gly), alanine (Ala), proline (Pro), valine (Val) and leucine (Leu). The reactions were performed as drying/wetting (hectorite) and temperature fluctuation (silica and alumina) experiments at 85 °C. The reactivity of amino acids decreased in order Gly > Ala > Pro ≈ Val ≈ Leu. The highest catalytic efficiency was observed for alumina, the only catalyst producing oligopeptides in all investigated reaction systems. The peptide bond formation on alumina is probably catalyzed by the same sites and via similar reaction mechanisms as some alumina-catalyzed dehydration reactions used in industrial chemistry.

引用

页码：451 / 461

页数：10