Toward a systems biology approach to investigate cellular networks in normal and malignant B cells

被引：0
作者：
K Basso
机构：
[1] Institute for Cancer Genetics,Department of Pediatrics
[2] Columbia University,undefined
[3] University of Padova,undefined
来源：
Leukemia | 2009年 / 23卷
关键词：
B cells; systems biology; cellular network;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In recent years, we experienced an increasing development of new technologies that aim to comprehensively dissect the molecular genetics of cellular phenotypes. Pioneering studies have been performed on leukemia and lymphoma and then extended to many other types of malignancies. Genome-wide technologies allow taking snapshots of defined cellular context from an unbiased angle highlighting a complexity that we still struggle to fully interpret. The increasing availability of technologies to detect genetic, transcriptional and post-transcriptional characteristics of cellular systems needs to be associated with the development of computational tools to fully investigate these data in an integrated way. The evolution of different genome-wide technologies as well as data mining and integration tools will be discussed following studies performed on normal and malignant human mature B cells.
引用
收藏
页码：1219 / 1225
页数：6
相关论文
共 185 条
  • [1] Kuppers R(2005)Mechanisms of B-cell lymphoma pathogenesis Nat Rev Cancer 5 251-262
  • [2] Kuppers R(2001)Mechanisms of chromosomal translocations in B cell lymphomas Oncogene 20 5580-5594
  • [3] Dalla-Favera R(2008)Germinal centres: role in B-cell physiology and malignancy Nat Rev Immunol 8 22-33
  • [4] Klein U(2001)Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas Nature 412 341-346
  • [5] Dalla-Favera R(2004)Aberrant somatic hypermutation targets an extensive set of genes in diffuse large B-cell lymphoma Blood (ASH Annual Meeting Abstracts) 104 1528-297
  • [6] Pasqualucci L(2004)MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 281-537
  • [7] Neumeister P(1999)Molecular classification of cancer: class discovery and class prediction by gene expression monitoring Science 286 531-1638
  • [8] Goossens T(2001)Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells J Exp Med 194 1625-1647
  • [9] Nanjangud G(2001)Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia J Exp Med 194 1639-8232
  • [10] Chaganti RS(2003)The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival Cancer Res 63 8226-68
12345678910