Polymorphisms in interleukins 17A and 17F genes and periodontitis: results from a meta-analysis

被引：0
作者：
Felipe Rodolfo Pereira da Silva
Larissa dos Santos Pessoa
Any Carolina Cardoso Guimarães Vasconcelos
Weberson de Aquino Lima
Even Herlany Pereira Alves
Daniel Fernando Pereira Vasconcelos
机构：
[1] Federal University of Piaui,Laboratory of Histological Analysis and Preparation (LAPHIS)
[2] Education Institute of Parnaiba Valley (IESVAP),Medicine School
[3] Federal University of Rio Grande do Norte,undefined
[4] Universidade Federal do Piauí – UFPI,undefined
来源：
Molecular Biology Reports | 2017年 / 44卷
关键词：
Cytokines; Chronic periodontitis; Aggressive periodontitis; Genetic; Genomics; Risk factors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Polymorphisms in inflammatory genes such as interleukins 17A and 17F are associated with the risk of development of periodontitis, although the results remain contradictory. Hence, the aim of this study was perform a meta-analysis focusing on two polymorphisms (rs2275913 and rs763780) in interleukins 17A and 17F genes, respectively, in both chronic (CP) and aggressive periodontitis (AgP). A review in literature was performed in several databases for studies published before 25, September 2016. The meta-analysis was obtained through the review manager statistical software (version 5.2) with odds ratio (OR) calculation and funnel plot (P < 0.05) for heterogeneity, as well as the comprehensive meta-analysis software (version 3.3.070) for the assessment of publication bias. Seven articles with 1540 participants composed the results in which the mutant allele in the rs2275913 polymorphism did not present significant association with the risk of CP or AgP (OR 1.56, 95% CI 0.77, 3.15, P = 0.21; OR 1.12, 95% CI 0.05, 23.44, P = 0.94, respectively) nor was the mutant allele in rs763780 associated with the risk of CP (OR 1.19, 95% CI 0.80, 1.76, P = 0.39) or AgP (OR 1.07, 95% CI 0.63, 1.84, P = 0.79). No bias of publication was observed by Egger’s and Begg’s tests in any allelic evaluation. This meta-analysis showed a non-significant association between the polymorphisms rs2275913 and rs763780 in interleukins 17A and 17F genes and chronic and aggressive periodontitis in the allelic evaluation.
引用
收藏
页码：443 / 453
页数：10
相关论文
共 201 条
  • [1] Jiang L(2014)Association between cyclooxygenase-2 gene polymorphisms and risk of periodontitis: a meta-analysis involving 5653 individuals Mol Biol Rep 41 4795-4801
  • [2] Weng H(2015)Periodontal disease classifications revisited Eur J Oral Sci 123 385-389
  • [3] Chen MY(2013)Risk factors for periodontal disease Periodontol 2000 62 59-94
  • [4] López R(2014)Genetic risk assessment of periodontal disease in healthy patients J Forensic Res 6 1-2
  • [5] Baelum V(2013)Variability of the fimA gene in Med Oral Patol Oral Cir Bucal 18 e100-e105-378
  • [6] Genco RJ(2013) isolated from periodontitis and non-periodontitis patients Hum Immunol 74 371-e14
  • [7] Borgnakke WS(2017)Association between interleukin-1β C (3953/4) T polymorphism and chronic periodontitis: evidence from a meta-analysis Med Oral Patol Oral Cir Bucal 22 e7-5203
  • [8] Carinci F(2013)Relationship between -889 C/T polymorphism in interleukin-1A gene and chronic periodontitis: evidence from a meta-analysis with new published findings Mol Biol Rep 40 5191-52
  • [9] Palmiere A(2014)Association between tumor necrosis factor-α promoter -308 A/G, -238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: a meta-analysis Inflamm Res 63 45-444
  • [10] Girardi A(2004)Interleukin-18 promoter polymorphisms and plasma levels are associated with increased risk of periodontitis: a meta-analysis Trends Genet 20 439-5
12345678910