Peroxisome Proliferator-Activated Receptor-γNovel Therapeutic Target Linking Adiposity, Insulin Resistance, and Atherosclerosis

被引：0
作者：
Alper Kepez
Ali Oto
Selcuk Dagdelen
机构：
[1] Hacettepe University,Faculty of Medicine Cardiology Department
[2] Hacettepe University Faculty of Medicine,Endocrinology Department
来源：
BioDrugs | 2006年 / 20卷
关键词：
Insulin Resistance; Adipose Tissue; Rosiglitazone; White Adipose Tissue; Hepatic Steatosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Insulin resistance and obesity is a common health problem in the industrialized world. As a result of the availability of high-calorie food and a reduction in energy expenditure, maladaptive metabolic processes may interfere with the action of insulin and increase susceptibility for the development of atherosclerotic cardiovascular diseases. With the advent of peroxisome proliferator-activated receptors (PPARs), the mechanisms of this maladaptation and its relationship to insulin resistance syndrome components have become less obscure, promising new therapeutic approaches for this common problem. In this review we first focus on the molecular structure and cellular mechanisms of action of these receptors and then discuss how PPAR-γ, a PPAR isoform, provides a link between adiposity, insulin resistance, and atherosclerosis.
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页码：121 / 135
页数：14
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