Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells

被引:0
作者
Antonio González-Sarrías
Juan Antonio Giménez-Bastida
María Ángeles Núñez-Sánchez
Mar Larrosa
María Teresa García-Conesa
Francisco A. Tomás-Barberán
Juan Carlos Espín
机构
[1] CEBAS-CSIC,Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology
来源
European Journal of Nutrition | 2014年 / 53卷
关键词
Urolithins; Ellagic acid; Glucuronide; Cell cycle; Colon cancer; Phase-II metabolism;
D O I
暂无
中图分类号
学科分类号
摘要
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收藏
页码:853 / 864
页数:11
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[1]  
Jemal A(2011)Global cancer statistics CA Cancer J Clin 61 69-90
[2]  
Bray F(2006)Dietary polyphenolic phytochemicals-promising cancer chemopreventive agents in humans? A review of their clinical properties Int J Cancer 120 451-458
[3]  
Center MM(2007)Polyphenolic compounds in chemoprevention of colon cancer-targets and signalling pathways Anticancer Agents Med Chem 7 559-575
[4]  
Ferlay J(2011)Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds Mol Nutr Food Res 55 32-45
[5]  
Ward E(2000)Ellagitannins-nature, occurrence and dietary burden J Sci Food Agric 80 118-125
[6]  
Forman D(2005)Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds J Agric Food Chem 53 5571-5576
[7]  
Thomasset SC(2010)Ellagitannins, ellagic acid and vascular health Mol Asp Med 31 513-539
[8]  
Berry DP(2007)Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans J Agric Food Chem 55 10476-10485
[9]  
Garcea G(2009)Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1 J Agric Food Chem 57 5623-5632
[10]  
Marczylo T(2011)UV and MS identification of urolithins and nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals J Agric Food Chem 59 1152-1162