Nucleotide excision repair is impaired by binding of transcription factors to DNA

被引：0
|
作者：
Radhakrishnan Sabarinathan
Loris Mularoni
Jordi Deu-Pons
Abel Gonzalez-Perez
Núria López-Bigas
机构：
[1] Research Program on Biomedical Informatics,
[2] IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra,undefined
[3] Institució Catalana de Recerca i Estudis Avançats (ICREA),undefined
来源：
Nature | 2016年 / 532卷
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学科分类号：
摘要：
An analysis of cancer genomic data reveals an increased rate of somatic mutations at active transcription factor binding sites located both within promoter regions and distal from genes; the increased mutation rate at these genomic regions can be explained by reduced accessibility of the protein-bound DNA to nucleotide excision repair machinery.
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页码：264 / 267
页数：3
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