Nucleotide excision repair is impaired by binding of transcription factors to DNA

被引：0

作者：

Radhakrishnan Sabarinathan

Loris Mularoni

Jordi Deu-Pons

Abel Gonzalez-Perez

Núria López-Bigas

机构：

[1] Research Program on Biomedical Informatics,

[2] IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra,undefined

[3] Institució Catalana de Recerca i Estudis Avançats (ICREA),undefined

来源：

Nature | 2016年 / 532卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An analysis of cancer genomic data reveals an increased rate of somatic mutations at active transcription factor binding sites located both within promoter regions and distal from genes; the increased mutation rate at these genomic regions can be explained by reduced accessibility of the protein-bound DNA to nucleotide excision repair machinery.

引用

页码：264 / 267

页数：3

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