Rhabdomyoblastic Differentiation in Head and Neck Malignancies Other Than Rhabdomyosarcoma

被引：26
作者：
Bishop J.A. [1 ]
Thompson L.D.R. [2 ]
Cardesa A. [3 ]
Barnes L. [4 ]
Lewis J.S. [5 ]
Jr. [5 ]
Triantafyllou A. [6 ]
Hellquist H. [7 ]
Stenman G. [8 ]
Hunt J.L. [9 ]
Williams M.D. [10 ]
Slootweg P.J. [11 ]
Devaney K.O. [12 ]
Gnepp D.R. [13 ]
Wenig B.M. [14 ]
Rinaldo A. [15 ]
Ferlito A. [1 ]
机构：
[1] Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins University, 401 N. Broadway, Weinberg 2249, Baltimore, 21231, MD
[2] Southern California Permanente Medical Group, Woodland Hills, CA
[3] Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona
[4] Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA
[5] Departments of Pathology and Immunology and Otolaryngology Head and Neck Surgery, Washington University in St. Louis, St. Louis, MO
[6] Pathology Department, Liverpool Clinical Laboratories, Liverpool
[7] Departamento de Ciências, Biomédicas e Medicina, Universidade do Algarve, Faro
[8] Sahlgrenska Cancer Center, Department of Pathology, University of Gothenburg, Gothenburg
[9] Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR
[10] Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
[11] Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen
[12] Department of Pathology, Allegiance Health, Jackson, MI
[13] Head and Neck Pathology, CBLPath, Warwick, RI
[14] Department of Pathology, Beth Israel Medical Center, New York, NY
[15] University of Udine School of Medicine, Udine
来源：
Head and Neck Pathology | 2015年 / 9卷 / 4期
关键词：
Head and neck malignancies; MyoD1; Myogenin; Rhabdomyoblastic differentiation; Rhabdomyosarcoma; Skeletal muscle differentiation; Soft tissue sarcomas;
D O I：
10.1007/s12105-015-0624-2
中图分类号：
学科分类号：
摘要：
Rhabdomyosarcoma is a relatively common soft tissue sarcoma that frequently affects children and adolescents and may involve the head and neck. Rhabdomyosarcoma is defined by skeletal muscle differentiation which can be suggested by routine histology and confirmed by immunohistochemistry for the skeletal muscle-specific markers myogenin or myoD1. At the same time, it must be remembered that when it comes to head and neck malignancies, skeletal muscle differentiation is not limited to rhabdomyosarcoma. A lack of awareness of this phenomenon could lead to misdiagnosis and, subsequently, inappropriate therapeutic interventions. This review focuses on malignant neoplasms of the head and neck other than rhabdomyosarcoma that may exhibit rhabdomyoblastic differentiation, with an emphasis on strategies to resolve the diagnostic dilemmas these tumors may present. Axiomatically, no primary central nervous system tumors will be discussed. © 2015, Springer Science+Business Media New York.
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页码：507 / 518
页数：11
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