Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial

[1] Minucci S(2006)Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer Nat Rev Cancer 6 38-51

[2] Pelicci PG(2001)Histone deacetylases and cancer: causes and therapies Nat Rev Cancer 1 194-202

[3] Marks P(2001)Histone acetylation and disease Cell Mol Life Sci 58 728-736

[4] Rifkind RA(2001)Histone acetylation and the cell-cycle in cancer Front Biosci 6 D610-29

[5] Richon VM(2004)Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer Tumour Biol 25 134-140

[6] Timmermann S(2005)Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer Clin Cancer Res 11 1021-1027

[7] Lehrmann H(2008)DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer Gastroenterology 135 142-151

[8] Polesskaya A(2009)Histone deacetylase inhibitors: design, structure-activity relationships and therapeutic implications for cancer Anticancer Agents Med Chem 9 661-692

[9] Wang C(2000)Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo Cancer Res 60 5165-5170

[10] Fu M(2007)Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL) Blood 109 31-39

[1] Minucci S(2006)Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer Nat Rev Cancer 6 38-51

[2] Pelicci PG(2001)Histone deacetylases and cancer: causes and therapies Nat Rev Cancer 1 194-202

[3] Marks P(2001)Histone acetylation and disease Cell Mol Life Sci 58 728-736

[4] Rifkind RA(2001)Histone acetylation and the cell-cycle in cancer Front Biosci 6 D610-29

[5] Richon VM(2004)Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer Tumour Biol 25 134-140

[6] Timmermann S(2005)Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer Clin Cancer Res 11 1021-1027

[7] Lehrmann H(2008)DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer Gastroenterology 135 142-151

[8] Polesskaya A(2009)Histone deacetylase inhibitors: design, structure-activity relationships and therapeutic implications for cancer Anticancer Agents Med Chem 9 661-692

[9] Wang C(2000)Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo Cancer Res 60 5165-5170

[10] Fu M(2007)Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL) Blood 109 31-39