Gene Expression for the Renin System in the Myocardium of Hypertensive ISIAH Rats

被引：0
|
作者：
L. A. Fedoseeva
M. A. Ryazanova
G. M. Dymshits
A. L. Markel
机构：
[1] Siberian Division of the Russian Academy of Sciences,Institute of Cytology and Genetics
[2] Novosibirsk State University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2009年 / 148卷
关键词：
cardiac renin-angiotensin system; ISIAH rats; water deprivation; angiotensinconverting enzyme; angiotensin type 1A receptor;
D O I：
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摘要：
The concentration of mRNA for angiotensin-converting enzyme (ACE) and angiotensin type 1A receptor (AT1A) in the myocardium of hypertensive ISIAH rats and normotensive WAG rats was measured by real-time PCR. Gene expression of the angiotensin type 1A receptor in the myocardium of 4-month-old ISIAH rats was lower than in WAG rats. The content of mRNA for angiotensin-converting enzyme in the myocardium of adult ISIAH rats was elevated by 80%. Therefore, the development of myocardial hypertrophy anticipates the increase in enzyme expression in the myocardium. Water deprivation (17 h) was accompanied by a decrease in the concentration of mRNA for angiotensin-converting enzyme in the myocardium of ISIAH rats, which did not differ from that in normotensive animals. Our results suggest that the decrease in cardiac preload and increase in plasma renin activity during dehydration reduce requirements for hyperactivity of the local cardiac renin—angiotensin system.
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页码：627 / 630
页数：3
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