A systematic two-sample and bidirectional MR process highlights a unidirectional genetic causal effect of allergic diseases on COVID-19 infection/severity

被引：0
作者：
Xiao-tong Chen
Shuai Zhi
Xin-yu Han
Jian-wei Jiang
Guang-ming Liu
Shi-tao Rao
机构：
[1] Fujian Medical University,Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, Institute of Precision Medicine, School of Medical Technology and Engineering
[2] Jimei University,Xiamen Key Laboratory of Marine Functional Food, College of Ocean Food and Biological Engineering, Fujian Provincial Engineering Technology Research Center of Marine Functional Food
[3] The Chinese University of Hong Kong,School of Biomedical Sciences
来源：
Journal of Translational Medicine | / 22卷
关键词：
Allergic diseases; Asthma; COVID-19 infection/severity; GWAS summary statistics; Mendelian randomization; Molecular mechanism; Immune-related cells; Hematological traits;
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摘要：
We performed a two-sample, bidirectional Mendelian randomization study for five types of allergic diseases with COVID-19 infection/severity (critically ill, hospitalized, and infection cases), and also further elucidated the potential underlying molecular mechanisms.Our MR analyses consistently suggest a unidirectional protective causal effect of asthma on COVID-19 infection/severity, but the reverse is not true.Food allergies such as shrimp allergy showed significant causal correlations with the risk of COVID-19 phenotypes.Allergic diseases may be causally correlated with COVID-19 infection/severity by inducing abnormal fluctuations of multiple immune-related cells and hematological traits in peripheral blood.The findings call for more attention to clinical monitoring of hematological traits and may be beneficial in developing effective therapeutic strategies for allergic patients following infection with COVID-19.
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