Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment

被引:0
作者
Chao Zhong
Kairong Cui
Christoph Wilhelm
Gangqing Hu
Kairui Mao
Yasmine Belkaid
Keji Zhao
Jinfang Zhu
机构
[1] Molecular and Cellular Immunoregulation Unit,
[2] Laboratory of Immunology,undefined
[3] National Institute of Allergy and Infectious Diseases,undefined
[4] National Institutes of Health,undefined
[5] Systems Biology Center,undefined
[6] National Heart,undefined
[7] Lung and Blood Institute,undefined
[8] National Institutes of Health,undefined
[9] Laboratory of Parasitic Diseases,undefined
[10] National Institute of Allergy and Infectious Diseases,undefined
[11] National Institutes of Health,undefined
[12] Institute of Clinical Chemistry and Clinical Pharmacology,undefined
[13] University Hospital Bonn,undefined
[14] University of Bonn,undefined
[15] Laboratory of System Biology,undefined
[16] National Institute of Allergy and Infectious Diseases,undefined
[17] National Institutes of Health,undefined
来源
Nature Immunology | 2016年 / 17卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Group 3 innate lymphoid cells have low expression of the transcription factor GATA-3. Zhu and colleagues show that despite its low expression, GATA-3 is essential for the homeostasis, further maturation and effector function of lineage-committed group 3 innate lymphoid cells.
引用
收藏
页码:169 / 178
页数:9
相关论文
共 47 条
  • [1] Spits H(2013)Innate lymphoid cells–a proposal for uniform nomenclature Nat. Rev. Immunol. 13 145-149
  • [2] Hoyler T(2012)The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells Immunity 37 634-648
  • [3] Yagi R(2014)The transcription factor GATA-3 is critical for the development of all IL-7Ralpha-expressing innate lymphoid cells Immunity 40 378-388
  • [4] Klein Wolterink RG(2013)Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells Proc. Natl. Acad. Sci. USA 110 10240-10245
  • [5] Mjösberg J(2012)The transcription factor GATA-3 is essential for the function of human type 2 innate lymphoid cells Immunity 37 649-659
  • [6] Moro K(2010)Innate production of T Nature 463 540-544
  • [7] Neill DR(2010)2 cytokines by adipose tissue-associated c-Kit Nature 464 1367-1370
  • [8] Price AE(2010)Sca-1 Proc. Natl. Acad. Sci. USA 107 11489-11494
  • [9] Satoh-Takayama N(2008) lymphoid cells Immunity 29 958-970
  • [10] Buonocore S(2010)Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity Nature 464 1371-1375