Synthesis of 3-hydroxy-1-methyl-2-(methylthio) pyrrole from methyl isothiocyanate and prop-2-yn-1-ol

被引：0

作者：

L. Brandsma

N. A. Nedolya

B. A. Trofimov

机构：

[1] Utrecht University,Department of Preparative Organic Chemistry

[2] Siberian Branch of the Russian Academy of Sciences,A. E. Favorsky Irkutsk Institute of Chemistry

来源：

Russian Chemical Bulletin | 2000年 / 49卷

关键词：

prop-2-yn-1-ol; ethoxyethene; 1-(1-ethoxyethoxy)allene; lithiation; methyl isothiocyanate; 2-(1-ethoxyethoxy)buta-2,3-dienimidothioate; cyclization; 3-hydroxy-1-methyl-2-(methylthio)pyrrole; keto-enol tautomerism;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A methylated adduct of lithiated 1-(1-ethoxyethoxy)allene and methyl isothiocyanate undergoes intramolecular cyclization in the presence of CuBr to give 3-(1-ethoxyethoxy)-1-methyl-2-(methylthio)pyrrole. The methanolysis of the latter affords 3-hydroxy-1-methyl-2-(methylthio)pyrrole.

引用

页码：1634 / 1636

页数：2