Various ligand-coated ultrasmall gadolinium-oxide nanoparticles: Water proton relaxivity and in-vivo T1 MR image

被引：0

作者：

Ja Young Park

Sung June Kim

Gang Ho Lee

Seonguk Jin

Yongmin Chang

Ji Eun Bae

Kwon Seok Chae

机构：

[1] College of Natural Sciences,Department of Chemistry and Department of Nanoscience and Nanotechnology

[2] Kyungpook National University (KNU),Department of Molecular Medicine and Medical & Biological Engineering and Department of Nanoscience and Nanotechnology

[3] School of Medicine,Department of Nanoscience and Nanotechnology

[4] KNU and Hospital,Department of Biology Education

[5] KNU,undefined

[6] Teachers’ College,undefined

[7] KNU,undefined

来源：

Journal of the Korean Physical Society | 2015年 / 66卷

关键词：

Surface coating; Ultrasmall Gd; O; nanoparticle; Water proton relaxivity; Magnetic resonance imaging;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Surface coating of nanoparticles with ligands is essential in magnetic resonance imaging (MRI) because of solubility in water and biocompatibility. In this study, five organic molecules were used for surface coating of ultrasmall gadolinium-oxide (Gd2O3) nanoparticles (davg = 2.0 nm). All of the samples showed large longitudinal (r1) and transverse (r2) water proton relaxivities with r2/r1 ratios that were close to one, corresponding to ideal conditions for T1 MRI contrast agents. Finally, in-vivo T1 MR images were acquired to prove the effectiveness of the surface-coated ultrasmall Gd2O3 nanoparticles as a T1 MRI contrast agent.

引用

页码：1295 / 1302

页数：7

共 3 条

[1] Various ligand-coated ultrasmall gadolinium-oxide nanoparticles: Water proton relaxivity and in-vivo T1 MR image
Park, Ja Young
Kim, Sung June
Lee, Gang Ho
Jin, Seonguk
Chang, Yongmin
Bae, Ji Eun
Chae, Kwon Seok
JOURNAL OF THE KOREAN PHYSICAL SOCIETY, 2015, 66 (08) : 1295 - 1302
[2] Synthesis Of PEG-Coated, Ultrasmall, Manganese-Doped Iron Oxide Nanoparticles With High Relaxivity For T1/T2 Dual-Contrast Magnetic Resonance Imaging
Xiao, Shilin
Yu, Xian
Zhang, Liang
Zhang, Ya
Fan, Weijie
Sun, Tao
Zhou, Chunyu
Liu, Yun
Liu, Yiding
Gong, Mingfu
Zhang, Dong
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14 : 8499 - 8507
[3] Polyaspartic Acid-Coated Paramagnetic Gadolinium Oxide Nanoparticles as a Dual-Modal T1 and T2 Magnetic Resonance Imaging Contrast Agent
Marasini, Shanti
Yue, Huan
Ghazanfari, Adibehalsadat
Ho, Son Long
Park, Ji Ae
Kim, Soyeon
Cha, Hyunsil
Liu, Shuwen
Tegafaw, Tirusew
Ahmad, Mohammad Yaseen
Al Saidi, Abdullah Khamis Ali
Zhao, Dejun
Liu, Ying
Chae, Kwon-Seok
Chang, Yongmin
Lee, Gang Ho
APPLIED SCIENCES-BASEL, 2021, 11 (17):

← 1 →