Synthesis and structure of new 3,7-diazabicyclo[3.3.1]nonane derivatives

被引：0
作者：
E. A. Chigorina
K. A. Frolov
V. V. Dotsenko
A. S. Goloveshkin
I. S. Bushmarinov
S. G. Krivokolysko
机构：
[1] State Scientific-Research Institute of Chemical Reagents and High Purity Substances (FSUE IREA),ChemEx Laboratory
[2] Lugansk State Medical University,A. N. Nesmeyanov Institute of Organoelement Compounds
[3] Vladimir Dal´ Lugansk State University,undefined
[4] Kuban State University,undefined
[5] North Caucasus Federal University,undefined
[6] Russian Academy of Sciences,undefined
来源：
Russian Chemical Bulletin | 2016年 / 65卷
关键词：
aminomethylation; Guareschi imides; bispidinates; 3-cyano-1,4,5,6-tetrahydropyridin-2-olates; 3-cyano-1,4,5,6-tetrahydropyridine-2-thiolates; 3-cyano-1,4,5,6-tetrahydropyridine-2-selenolates; Mannich reaction; 3,7-diazabicyclo[3.3.1]nonanes; 1,3,5-thiadiazines; X-ray diffraction analysis;
D O I：
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中图分类号：
学科分类号：
摘要：
Aminomethylation of triethylammonium 4-aryl-3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridin-2-olates and their sulfur and selenium analogs, as well as the structure of formed products, were studied in details. The reaction is of general character and leads to the formation of 7-substituted 9-aryl-2,4-dioxo-, 9-aryl-4-oxo-2-thioxo-, 9-aryl-4-oxo-2-selenoxo-3,7-diazabicyclo[3.3.1]nonane derivatives or their salts. The structures of ethyl 9-(2-chlorophenyl)-5-cyano-7-(4-methylphenyl)-2-oxo-4-thioxo-3,7-diazabicyclo[3.3.1]nonane-1-carboxylate (as a complex with N-methylmorpholine) and triethylammonium salt of 7-benzyl-4-oxo-2-selenoxo-9-(2-thienyl)-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarbonitrile were studied by X-ray crystallography.
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页码：2260 / 2269
页数：9
相关论文
共 135 条
[1]  
Zefirov N. S.(1973)undefined Russ. Chem. Rev. 42 190-undefined
[2]  
Rogozina S. V.(1981)undefined Chem. Rev. 81 149-undefined
[3]  
Jeyaraman R.(1991)undefined Top. Stereochem. 20 171-undefined
[4]  
Avila S.(1996)undefined J. Med. Chem. 39 2559-undefined
[5]  
Zefirov N. S.(1990)undefined Eur. J. Med. Chem. 25 1-undefined
[6]  
Palyulin V. A.(1998)undefined CNS Drug Rev. 4 54-undefined
[7]  
Garrison G. L.(2000)undefined Arch. Pharm. 333 226-undefined
[8]  
Berlin K. D.(2000)undefined J. Med. Chem. 43 3746-undefined
[9]  
Scherlag B. J.(2003)undefined J. Med. Chem. 46 1383-undefined
[10]  
Lazzara R.(2005)undefined J. Pharmacol. Exp. Therap. 312 220-undefined
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