Synthesis, characterization, and POM analysis of novel bioactive imidazolium-based ionic liquids

被引：0
作者：
Mouslim Messali
Mohamed R. Aouad
Adeeb A.-S. Ali
Nadjet Rezki
Taibi Ben Hadda
Belkheir Hammouti
机构：
[1] Taibah University,Department of Chemistry
[2] University of Sciences and Technology Mohamed Boudiaf,Department of Chemistry, Faculty of Sciences
[3] Laboratoire de Chimie & Electrochimie des Complexes Métalliques (LCECM) USTO-MB,Laboratoire de Chimie des Matériaux, Faculté des Sciences
[4] Université Mohammed Premier,LCAE
[5] Université Mohammed Premier,URAC18, Faculté des Sciences
来源：
Medicinal Chemistry Research | 2015年 / 24卷
关键词：
Green procedure; Ionic liquids; Ultrasound irradiation; Antibacterial, antifungal and anticancer activity; Petra/Osiris/Molinspiration (POM) analyses; Bioavailability;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An efficient green ultrasound-assisted procedure for the preparation of five new functionalized 1-alkyl-3-butylimidazolium ionic liquids (ILs) 2–6 is described. Their structures were characterized by FT-IR, 1H NMR, and 13C NMR spectroscopy and mass spectrometry. The newly synthesized compounds were screened for their antimicrobial and anticancer activities. The former revealed that the ILs exhibited promising activity compared with standard drugs. Moreover, IL 4 was found to be a very promising antiproliferative agent against the human hepatocellular carcinoma (HEPG2), human breast adenocarcinoma (MCF7), and colon carcinoma (HCT116) cell lines and consistently produced low IC50 values.
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页码：1387 / 1395
页数：8
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