Mathematical modeling of delayed calcium deregulation in brain neurons caused by hyperstimulation of glutamate receptors

被引：0

作者：

Chastukhin D.S. ^{[1
,2
]}

Borodin A.V. ^{[1
,2
]}

Khodorov B.I. ^{[1
]}

机构：

[1] Institute of General Pathology and Pathophysiology, Moscow

[2] Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region

来源：

Biophysics | 2014年 / 59卷 / 2期

关键词：

delayed calcium deregulation; glutamate; intracellular Ca; ionic homeostasis modeling;

D O I：

10.1134/S0006350914020067

中图分类号：

学科分类号：

摘要：

Mathematical model presented in this paper is based on the data obtained in experimental studies of the mechanism of glutamate-induced deregulation of Ca2+ homeostasis and mitochondrial depolarization in cultured nerve cells. According to our hypothesis the secondary Ca2+ increase during a prolonged glutamate challenge is mainly due to a profound mitochondrial depolarization which stops mitochondrial Ca2+ uptake in the face of continuous Ca2+ influx into the cell. It is supposed that a progressive decrease in mitochondrial NADH during glutamate exposure greatly enhances sensitivity of mitochondria to intracellular Ca-neurotoxicity. A system of equations developed in this work made it possible to provide a satisfactory simulation of most of experimental events observed in the present study. © 2014 Pleiades Publishing, Inc.

引用

页码：236 / 247

页数：11

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