Gasdermin-d Played a Critical Role in the Cyclic Stretch–Induced Inflammatory Reaction in Human Periodontal Ligament Cells

被引：0
作者：
Jiabao Zhuang
Yingying Wang
Fang Qu
Yaqin Wu
Dan Zhao
Chun Xu
机构：
[1] Shanghai Jiao Tong University School of Medicine,Department of Prosthodontics, Shanghai Ninth People’s Hospital, College of Stomatology
[2] National Clinical Research Center for Oral Diseases,undefined
[3] Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology,undefined
来源：
Inflammation | 2019年 / 42卷
关键词：
cyclic stretch; human periodontal ligament cells; gasdermin-d; inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
It has been shown that cyclic stretch could induce inflammatory response such as pyroptosis and the release of IL-1β in human periodontal ligament cells, through activating inflammasome and related caspases. Though gasdermin-d (GSDMD) has been reported to be present in some inflammatory diseases and function as a crucial executioner of pyroptosis, the role of GSDMD in the stretch-induced inflammatory response in human periodontal ligament cells (HPDLCs) has not been well clarified. In this study, it was found that GSDMD was activated by cyclic stretch, and its activation affected the pyroptotic rate in HPDLCs, leading to the maturation and secretion of IL-1β and IL-18 ultimately. In addition, GSDMD was found to be regulated by caspase-1 directly. Nevertheless, the exact relationship between inflammasomes and GSDMD in the stretch-induced inflammatory response still needs to be further elucidated.
引用
收藏
页码：548 / 558
页数：10
相关论文
共 247 条
[1]  
McCulloch CA(2000)Role of physical forces in regulating the form and function of the periodontal ligament Periodontol 2000 56-72
[2]  
Lekic P(2016)Dynamic mechanical and nanofibrous topological combinatory cues designed for periodontal ligament engineering PLoS One 11 e0149967-997
[3]  
McKee MD(1998)Role of epidermal growth factor and its receptor in mechanical stress-induced differentiation of human periodontal ligament cells in vitro Archives of Oral Biology 43 987-8582
[4]  
Kim JH(2010)Periodontal regeneration using engineered bone marrow mesenchymal stromal cells Biomaterials 31 8574-17
[5]  
Kang MS(2001)Occlusal hypofunction causes changes of proteoglycan content in the rat periodontal ligament Journal of Periodontal Research 36 9-66
[6]  
Eltohamy M(2005)Investigation of periodontal ligament reaction upon excessive occlusal load—osteopontin induction among periodontal ligament cells Journal of Periodontal Research 40 59-97
[7]  
Kim TH(1992)Clinical diagnosis of trauma from occlusion and its relation with severity of periodontitis Journal of Clinical Periodontology 19 92-117
[8]  
Kim HW(2003)Occlusal forces as a risk factor for periodontal disease Periodontol 2000 111-1064
[9]  
Matsuda N(2014)Tense strain increased COX-2 expression and PGE2 release leading to weaking of the human amniotic membrane Placenta 35 1057-908
[10]  
Yokoyama K(2015)Cyclic stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells PeerJ 3 31483-429
12345678910