CD8+ T cells in systemic sclerosis

被引：0
作者：
Patrizia Fuschiotti
机构：
[1] University of Pittsburgh School of Medicine,Department of Immunology
来源：
Immunologic Research | 2011年 / 50卷
关键词：
Autoimmunity; Human; Fibrosis; IL-13; CD8; T cells; GATA-3;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Systemic sclerosis (SSc) is a progressive and highly debilitating autoimmune disorder characterized by inflammation, fibrosis, and vascular damage of the connective tissue. T cell-derived cytokines have been implicated in the induction of fibrosis. We found that high levels of the profibrotic type-2 cytokine IL-13 are produced by peripheral blood effector CD8+ T cells from SSc patients compared to normal controls. This abnormality correlates with increased expression of the transcription factor GATA-3 and the extent of skin fibrosis. Together, the data provide new insights into SSc pathogenesis and identify a specific T cell phenotype that can be used as a biomarker of immune dysfunction in patients with SSc and as a novel therapeutic target for this currently incurable disease.
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页码：188 / 194
页数：6
相关论文
共 241 条
[1]  
Varga J(2007)Systemic sclerosis: a prototypic multisystem fibrotic disorder J Clin Invest 117 557-567
[2]  
Abraham D(2003)Scleroderma epidemiology Rheum Dis Clin North Am 29 239-254
[3]  
Mayes MD(2001)Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts Arthritis Rheum 44 1359-1362
[4]  
Arnett FC(1998)Human cytomegalovirus and the vasculopathies of autoimmune diseases (especially scleroderma), allograft rejection, and coronary restenosis Arthritis Rheum 41 10-15
[5]  
Cho M(2000)Systemic sclerosis: environmental and occupational risk factors Curr Opin Rheumatol 12 520-526
[6]  
Chatterjee S(2005)Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k) J Biol Chem 280 16053-16065
[7]  
Aguilar MB(2004)Raynaud phenomenon and the vascular disease in scleroderma Curr Opin Rheumatol 16 718-722
[8]  
Reveille JD(2004)Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis Ann Intern Med 140 37-50
[9]  
Mayes MD(2004)Is systemic sclerosis an antigen-driven T cell disease? Arthritis Rheum 50 1721-1733
[10]  
Pandey JP(1992)Sequential dermal microvascular and perivascular changes in the development of scleroderma J Pathol 166 255-263
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