Atorvastatin alleviates left ventricular remodeling in isoproterenol-induced chronic heart failure in rats by regulating the RhoA/Rho kinase signaling pathway

被引:0
作者
Dingjun Sun
Fuwei Zhang
Tianyi Ma
Yixue Zhang
Zhongshu Liang
机构
[1] Central South University Xiangya School of Medicine Affiliated Haikou Hospital (Haikou People’s Hospital),Department of Cardiology
[2] The Third Xiangya Hospital of Central South University,Department of Cardiology
来源
Pharmacological Reports | 2020年 / 72卷
关键词
Atorvastatin; Left ventricular remodeling; Cardiac function; Chronic heart failure; Isoproterenol; RhoA/Rho kinase; Endothelial nitric oxide synthase;
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学科分类号
摘要
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页码:903 / 911
页数:8
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  • [31] Zhang L(2006)Upregulated Rho-kinase and increased phosphorylation of myosin-binding subunit of myosin phosphates are key players in a porcine coronary artery spasm model with interleukin-1beta Zhonghua Xin Xue Guan Bing Za Zhi 34 50-879
  • [32] Zhang S(2011)Novel mechanistic and clinical implications concerning the safety of statin discontinuation Pharmacol Rep 63 867-872
  • [33] Jiang H(2014)Atorvastatin attenuates involvement of RhoA/Rho-kinase pathway and NF-kappaB activation in hypoxic pulmonary hypertensive rats Chin Med J (Engl) 127 869-1161
  • [34] Sun A(2013)Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury J Urol 189 1155-253
  • [35] Wang Y(2007)Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase Hepatology 46 242-34
  • [36] Zou Y(2011)Key role of the RhoA/Rho kinase system in pulmonary hypertension Pulm Pharmacol Ther 24 14-38490
  • [37] Wood WG(2019)Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress Life Sci. 221 29-3946
  • [38] Eckert GP(2017)Apocynin attenuates left ventricular remodeling in diabetic rabbits Oncotarget 8 38482-1986
  • [39] Igbavboa U(2015)Atorvastatin improves cardiac function of rats with chronic cardiac failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release Eur Rev Med Pharmacol Sci 19 3940-undefined
  • [40] Muller WE(2007)Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy Diabetologia 50 1977-undefined