Prospects for redox-based therapy in neurodegenerative diseases

被引:0
作者
Avi L. Friedlich
M. Flint Beal
机构
[1] Weill Medical College of Cornell University,Department of Neurology and Neuroscience
来源
Neurotoxicity Research | 2000年 / 2卷
关键词
Alzheimer’s disease; Amyotrophic lateral sclerosis; Huntington’s disease; Oxidative damage; Neurodegeneration; Parkinson’s disease; Redox-based therapy; Transgenic mouse models;
D O I
暂无
中图分类号
学科分类号
摘要
Accumulating evidence supports a primary role for perturbations in redox metabolism in the pathogenesis of many neurodegenerative diseases. This evidence derives mainly from molecular genetic analysis, direct observation from post-mortem human brain, and biochemical, pathologic, and therapeutic studies in transgenic and other animal models of neurodegeneration. We review here the evidence for redox-mediated pathogenesis in neurodegenerative diseases. The emerging class of redox-based therapeutic agents is then discussed. Drugs of this class are distinguished by their proximate effect, which is oxidative and not phosphorylative.
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页码:229 / 237
页数:8
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